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- W2079176326 abstract "Activation of the caspase-dependent cell death pathways has been shown in focal seizures, but whether this occurs in prolonged generalized seizures is not known. We investigated whether the initiator caspase in the extrinsic pathway, caspase-8, or the intrinsic pathway, caspase-9, is activated during the first 24 h following lithium–pilocarpine-induced status epilepticus, when neuronal death is maximal and widespread. The thymuses of rats given methamphetamine were used as positive controls for caspase-3-activated cellular apoptosis. Following methamphetamine treatment, caspase-9 but not caspase-8 was activated in thymocytes. However, 6 or 24 h following status epilepticus, none of 26 brain regions studied showed either caspase-8 or -9 activation by immunohistochemistry, western blotting and enzyme activity assays. Our results provide evidence against the activation of the extrinsic and intrinsic caspase pathways in generalized seizures, which produce morphologically necrotic neurons with internucleosomal DNA cleavage (DNA laddering), a programmed process. In contrast, there is increasing evidence that caspase-independent programmed mechanisms play a prominent role in seizure-induced neuronal death." @default.
- W2079176326 created "2016-06-24" @default.
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- W2079176326 creator A5061290134 @default.
- W2079176326 creator A5087785384 @default.
- W2079176326 creator A5091709738 @default.
- W2079176326 date "2007-03-01" @default.
- W2079176326 modified "2023-09-23" @default.
- W2079176326 title "Caspase-dependent programmed cell death pathways are not activated in generalized seizure-induced neuronal death" @default.
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- W2079176326 doi "https://doi.org/10.1016/j.brainres.2006.12.029" @default.
- W2079176326 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17204252" @default.
- W2079176326 hasPublicationYear "2007" @default.
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