FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079177710> ?p ?o ?g. }

• W2079177710 endingPage "304" @default.
• W2079177710 startingPage "297" @default.
• W2079177710 abstract "GCSB-5 (traditional name: Chungpa-Juhn), an herbal medicine composed of 6 crude herbs (Saposhnikovia divaricata Schiskin, Achyranthis bidentata Blume, Acanthopanax sessiliflorum Seem, Cibotium baromets J. Smith, Glycine max Meriill, and Eucommia ulmoides Oliver), has been widely used in Asia for treatment of neuropathic and inflammatory diseases. This study investigated the protective effect of GCSB-5 against peripheral nerve injury in vitro and in vivo.After left sciatic nerve transection, rats received oral administration of GCSB-5 (30, 100, 300, and 600 mg/kg), or saline (vehicle), respectively, once daily for 8 weeks. Motor functional recovery and axonal nerve regeneration were evaluated by measurement of sciatic functional index (SFI), sensory regeneration distance, and gastrocnemius muscle mass ratio. The myelinated axon number was counted by morphometric analysis. In the in vitro study, the effects of GCSB-5 on H(2)O(2)-induced oxidative damage in SH-SY5Y cells were investigated by measurement of cell viability, production of reactive oxygen species (ROS), lipid peroxidation, release of lactate dehydrogenease (LDH), and cellular glutathione contents. Neurite outgrowth was also determined.After 8 weeks of nerve transection, SFI, regeneration distance, and gastrocnemius muscle mass ratio and myelinated axon number showed a significant decrease and these decreases were attenuated by GCSB-5. GCSB-5 significantly inhibited H(2)O(2)-induced cell death and oxidative stress, as evidenced by decreases in production of ROS and lipid peroxidation and release of LDH, and by increase in total GSH content.The neuroprotective effect afforded by GCSB-5 is due in part to reduced oxidative stress." @default.
• W2079177710 created "2016-06-24" @default.
• W2079177710 creator A5008666758 @default.
• W2079177710 creator A5037864229 @default.
• W2079177710 creator A5041670114 @default.
• W2079177710 creator A5045880815 @default.
• W2079177710 creator A5047011011 @default.
• W2079177710 creator A5088988274 @default.
• W2079177710 creator A5091003200 @default.
• W2079177710 date "2011-06-01" @default.
• W2079177710 modified "2023-09-23" @default.
• W2079177710 title "Protective effect of GCSB-5, an herbal preparation, against peripheral nerve injury in rats" @default.
• W2079177710 cites W1590457525 @default.
• W2079177710 cites W1606105957 @default.
• W2079177710 cites W1964235917 @default.
• W2079177710 cites W1969492748 @default.
• W2079177710 cites W1978197119 @default.
• W2079177710 cites W1979504930 @default.
• W2079177710 cites W1988398725 @default.
• W2079177710 cites W1996656084 @default.
• W2079177710 cites W2004870167 @default.
• W2079177710 cites W2005507063 @default.
• W2079177710 cites W2006363780 @default.
• W2079177710 cites W2007064404 @default.
• W2079177710 cites W2008877659 @default.
• W2079177710 cites W2012969681 @default.
• W2079177710 cites W2014260239 @default.
• W2079177710 cites W2023939284 @default.
• W2079177710 cites W2036318063 @default.
• W2079177710 cites W2037648324 @default.
• W2079177710 cites W2046970532 @default.
• W2079177710 cites W2058165942 @default.
• W2079177710 cites W2062746755 @default.
• W2079177710 cites W2071422853 @default.
• W2079177710 cites W2075669474 @default.
• W2079177710 cites W2083211973 @default.
• W2079177710 cites W2088608292 @default.
• W2079177710 cites W2111705857 @default.
• W2079177710 cites W2114918609 @default.
• W2079177710 cites W2120396832 @default.
• W2079177710 cites W2124020987 @default.
• W2079177710 cites W2135907032 @default.
• W2079177710 cites W2151456942 @default.
• W2079177710 doi "https://doi.org/10.1016/j.jep.2011.04.037" @default.
• W2079177710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21569830" @default.
• W2079177710 hasPublicationYear "2011" @default.
• W2079177710 type Work @default.
• W2079177710 sameAs 2079177710 @default.
• W2079177710 citedByCount "57" @default.
• W2079177710 countsByYear W20791777102013 @default.
• W2079177710 countsByYear W20791777102014 @default.
• W2079177710 countsByYear W20791777102015 @default.
• W2079177710 countsByYear W20791777102016 @default.
• W2079177710 countsByYear W20791777102017 @default.
• W2079177710 countsByYear W20791777102018 @default.
• W2079177710 countsByYear W20791777102019 @default.
• W2079177710 countsByYear W20791777102020 @default.
• W2079177710 countsByYear W20791777102021 @default.
• W2079177710 countsByYear W20791777102022 @default.
• W2079177710 countsByYear W20791777102023 @default.
• W2079177710 crossrefType "journal-article" @default.
• W2079177710 hasAuthorship W2079177710A5008666758 @default.
• W2079177710 hasAuthorship W2079177710A5037864229 @default.
• W2079177710 hasAuthorship W2079177710A5041670114 @default.
• W2079177710 hasAuthorship W2079177710A5045880815 @default.
• W2079177710 hasAuthorship W2079177710A5047011011 @default.
• W2079177710 hasAuthorship W2079177710A5088988274 @default.
• W2079177710 hasAuthorship W2079177710A5091003200 @default.
• W2079177710 hasConcept C105702510 @default.
• W2079177710 hasConcept C113246987 @default.
• W2079177710 hasConcept C126322002 @default.
• W2079177710 hasConcept C134018914 @default.
• W2079177710 hasConcept C181199279 @default.
• W2079177710 hasConcept C185592680 @default.
• W2079177710 hasConcept C202751555 @default.
• W2079177710 hasConcept C25498285 @default.
• W2079177710 hasConcept C2775872116 @default.
• W2079177710 hasConcept C2776151105 @default.
• W2079177710 hasConcept C2779530196 @default.
• W2079177710 hasConcept C2779959927 @default.
• W2079177710 hasConcept C2780829032 @default.
• W2079177710 hasConcept C2781149210 @default.
• W2079177710 hasConcept C48349386 @default.
• W2079177710 hasConcept C538909803 @default.
• W2079177710 hasConcept C55493867 @default.
• W2079177710 hasConcept C71924100 @default.
• W2079177710 hasConcept C98274493 @default.
• W2079177710 hasConceptScore W2079177710C105702510 @default.
• W2079177710 hasConceptScore W2079177710C113246987 @default.
• W2079177710 hasConceptScore W2079177710C126322002 @default.
• W2079177710 hasConceptScore W2079177710C134018914 @default.
• W2079177710 hasConceptScore W2079177710C181199279 @default.
• W2079177710 hasConceptScore W2079177710C185592680 @default.
• W2079177710 hasConceptScore W2079177710C202751555 @default.
• W2079177710 hasConceptScore W2079177710C25498285 @default.
• W2079177710 hasConceptScore W2079177710C2775872116 @default.
• W2079177710 hasConceptScore W2079177710C2776151105 @default.
• W2079177710 hasConceptScore W2079177710C2779530196 @default.

• next