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- W2079178108 abstract "We adopted a proteomics-based approach to gain insights into phenotypic differences between A/J and B10.SJL murine dysferlinopathy models.We optimized immunoblotting of dysferlin by preparing homogenates of the tibialis anterior (TA) muscle under several different conditions. We compared TA muscles of control, A/J, and B10.SJL mice for levels of dysferlin; dysferlin's partners MG53, annexin-A2, and caveolin-3; and the endoplasmic reticulum (ER) stress marker CHOP. We performed immunoelectron microscopy on control rat TA muscle to determine the precise location of dysferlin.RIPA (radioimmunoprecipitation assay) buffer and sonication improves immunoblotting of dysferlin. The ER stress marker CHOP is elevated in A/J muscle. Dysferlin is localized mostly to membranes close to the Z-disk that have been reported to be part of the Golgi, ER, and sarcoplasmic reticulum (SR) networks.ER stress might underlie phenotypic differences between A/J and B10.SJL mice and play a role in human dysferlinopathies." @default.
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- W2079178108 date "2014-07-14" @default.
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- W2079178108 title "Improved immunoblotting methods provide critical insights into phenotypic differences between two murine dysferlinopathy models" @default.
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- W2079178108 doi "https://doi.org/10.1002/mus.24220" @default.
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