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- W2079178237 abstract "The effect of GABA-mimetics on histaminergic activity in the mouse brain was investigated. Systemic administration of muscimol (2 and 5 mg/kg), THIP (5-15 mg/kg) and aminooxyacetic acid (AOAA) (25 mg/kg) but not baclofen (2.5-15 mg/kg) inhibited the pargyline (65 mg/kg)-induced accumulation of tele-methylhistamine (t-MH). There was no regional difference in the inhibitory effect of muscimol on the t-MH accumulation by pargyline treatment. Muscimol and AOAA also inhibited decrease in the histamine (HA) level induced by alpha-fluoromethylhistidine (50 mg/kg), a specific inhibitor of histidine decarboxylase. These results suggest that these GABA-mimetics reduce the HA turnover in the mouse brain." @default.
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- W2079178237 date "1986-01-01" @default.
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- W2079178237 title "Effects of GABA-Mimetic Drugs on Turnover of Histamine in the Mouse Brain" @default.
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- W2079178237 doi "https://doi.org/10.1254/jjp.41.403" @default.
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