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- W2079179542 abstract "Polyunsaturated fatty acids (PUFA: arachidonic and linoleic acid) release histamine from isolated purified rat serosal mast cells only in the presence of oxidizing systems such as phenobarbitalinduced rat liver microsomes, prostagtandin-H-synthetase (PHS) or soybean lipoxygenase. The release of mast cell histamine by activated PUFA has a long time-course and the electron microscopical features are consistent with an exocytotic secretion in the case of arachidonic acid and cell lysis in the case of linoleic acid. The phenomenon is associated with a significant increase in malonyldialdehyde (MDA) and conjugated diene generation, suggesting a relationship between histamine release and membrane lipid peroxidation. The secretion of histamine was inhibited by anti-free radical interventions such as d-mannitol, reduced glutathione and α-tocopherol. Some cyclooxygenase and lipoxygenase inhibitors, cimetidine and carnitine derivatives, are differentially active in the inhibition of mast cell histamine release by activated arachidonic acid. These results suggest that free radical derivatives of PUFA, generated by metabolic activation, trigger mast cell histamine release." @default.
- W2079179542 created "2016-06-24" @default.
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- W2079179542 date "1990-03-01" @default.
- W2079179542 modified "2023-10-17" @default.
- W2079179542 title "Histamine release from rat mast cells induced by metabolic activation of polyunsaturated fatty acids into free radicals" @default.
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- W2079179542 doi "https://doi.org/10.1016/0006-2952(90)90203-w" @default.
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