Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079181256> ?p ?o ?g. }
- W2079181256 endingPage "3235" @default.
- W2079181256 startingPage "3227" @default.
- W2079181256 abstract "FSH is a key component in assisted reproductive technologies. Because of rapid clearance of the hormone, patients have to be treated with daily injections. To address this problem, a long-acting FSH mutein was created by introduction of additional N-linked glycosylation into the molecule. New glycosylation sites were introduced by two different approaches: structure-aided, site-directed introduction of sites within the FSH molecule and addition of N-terminal extensions. A mutein with the extension sequence ANITVNITV at the N terminus of the α-chain (FSH1208) was efficiently glycosylated at both new sites. This resulted in a molecule with increased size and charge, factors known to reduce renal clearance of proteins. FSH1208 was found to have a 3- to 4-fold increased serum half-life, compared with wild-type recombinant FSH. Furthermore, in spite of a lower in vitro activity, FSH1208 had a markedly increased in vivo potency, as shown by increased ability to augment the ovarian weight and stimulate the serum estradiol levels in rats. These characteristics make FSH1208 a possible candidate for improved infertility treatment." @default.
- W2079181256 created "2016-06-24" @default.
- W2079181256 creator A5018502539 @default.
- W2079181256 creator A5022356371 @default.
- W2079181256 creator A5066890134 @default.
- W2079181256 creator A5074681520 @default.
- W2079181256 creator A5078518197 @default.
- W2079181256 creator A5085307336 @default.
- W2079181256 creator A5086158925 @default.
- W2079181256 creator A5086305282 @default.
- W2079181256 creator A5090713365 @default.
- W2079181256 date "2003-07-01" @default.
- W2079181256 modified "2023-10-18" @default.
- W2079181256 title "Glycosylation of an N-Terminal Extension Prolongs the Half-Life and Increases the in Vivo Activity of Follicle Stimulating Hormone" @default.
- W2079181256 cites W1497815765 @default.
- W2079181256 cites W1569589672 @default.
- W2079181256 cites W1589735909 @default.
- W2079181256 cites W1599956369 @default.
- W2079181256 cites W1966361056 @default.
- W2079181256 cites W1967642158 @default.
- W2079181256 cites W1979325667 @default.
- W2079181256 cites W1979782649 @default.
- W2079181256 cites W1982626008 @default.
- W2079181256 cites W1985116028 @default.
- W2079181256 cites W1989425331 @default.
- W2079181256 cites W1989858688 @default.
- W2079181256 cites W1990477940 @default.
- W2079181256 cites W1991013766 @default.
- W2079181256 cites W2001297734 @default.
- W2079181256 cites W2002922748 @default.
- W2079181256 cites W2003238372 @default.
- W2079181256 cites W2014314102 @default.
- W2079181256 cites W2019219968 @default.
- W2079181256 cites W2019499077 @default.
- W2079181256 cites W2028612664 @default.
- W2079181256 cites W2035238776 @default.
- W2079181256 cites W2040791684 @default.
- W2079181256 cites W2042476299 @default.
- W2079181256 cites W2043679919 @default.
- W2079181256 cites W2047317046 @default.
- W2079181256 cites W2048034139 @default.
- W2079181256 cites W2048800048 @default.
- W2079181256 cites W2049122170 @default.
- W2079181256 cites W2050971119 @default.
- W2079181256 cites W2063015454 @default.
- W2079181256 cites W2064928907 @default.
- W2079181256 cites W2067900905 @default.
- W2079181256 cites W2070927927 @default.
- W2079181256 cites W2071659082 @default.
- W2079181256 cites W2072985378 @default.
- W2079181256 cites W2076624138 @default.
- W2079181256 cites W2085864622 @default.
- W2079181256 cites W2088703956 @default.
- W2079181256 cites W2091186738 @default.
- W2079181256 cites W2092292088 @default.
- W2079181256 cites W2092560671 @default.
- W2079181256 cites W2099744576 @default.
- W2079181256 cites W2108049900 @default.
- W2079181256 cites W2108511043 @default.
- W2079181256 cites W2114793225 @default.
- W2079181256 cites W2120859766 @default.
- W2079181256 cites W2121226098 @default.
- W2079181256 cites W2131817370 @default.
- W2079181256 cites W2135819931 @default.
- W2079181256 cites W2144652798 @default.
- W2079181256 cites W2146229524 @default.
- W2079181256 cites W2149936339 @default.
- W2079181256 cites W2154031929 @default.
- W2079181256 cites W2157613837 @default.
- W2079181256 cites W2169173740 @default.
- W2079181256 cites W2170799379 @default.
- W2079181256 cites W2269671844 @default.
- W2079181256 cites W2407240320 @default.
- W2079181256 cites W2411746333 @default.
- W2079181256 cites W2412503111 @default.
- W2079181256 cites W4244325468 @default.
- W2079181256 doi "https://doi.org/10.1210/jc.2002-021201" @default.
- W2079181256 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12843169" @default.
- W2079181256 hasPublicationYear "2003" @default.
- W2079181256 type Work @default.
- W2079181256 sameAs 2079181256 @default.
- W2079181256 citedByCount "114" @default.
- W2079181256 countsByYear W20791812562012 @default.
- W2079181256 countsByYear W20791812562013 @default.
- W2079181256 countsByYear W20791812562014 @default.
- W2079181256 countsByYear W20791812562015 @default.
- W2079181256 countsByYear W20791812562016 @default.
- W2079181256 countsByYear W20791812562017 @default.
- W2079181256 countsByYear W20791812562018 @default.
- W2079181256 countsByYear W20791812562019 @default.
- W2079181256 countsByYear W20791812562020 @default.
- W2079181256 countsByYear W20791812562021 @default.
- W2079181256 countsByYear W20791812562023 @default.
- W2079181256 crossrefType "journal-article" @default.
- W2079181256 hasAuthorship W2079181256A5018502539 @default.
- W2079181256 hasAuthorship W2079181256A5022356371 @default.
- W2079181256 hasAuthorship W2079181256A5066890134 @default.
- W2079181256 hasAuthorship W2079181256A5074681520 @default.