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• W2079181573 endingPage "146" @default.
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• W2079181573 abstract "Successful cloning by somatic cell nuclear transfer (SCNT) is thought to require reprogramming of a somatic nucleus to a state of restored totipotentiality [Dean, W., Santos, F., Reik, W., 2003. Epigenetic programming in early mammalian development and following somatic cell nuclear transfer. Semin. Cell. Dev. Biol. 14, 93-100; Jouneau, A., Renard, J.P., 2003. Reprogramming in nuclear transfer. Curr. Opin. Genet. Dev. 13, 486-491; ]. Though SCNT-induced reprogramming is reminiscent of the reprogramming that occurs after fertilization, reprogramming a differentiated nucleus to an embryonic state is delayed and incomplete in comparison (for review, see ). This is likely due to the existence of an epigenetic-based cellular memory, or program, that serves to regulate global patterns of gene expression, and is the basis of a genome defense mechanism that silences viruses and transposons. The mechanisms of this memory include CpG methylation and modification of histones. Recent evidence by Feng et al. [Feng, Y.-Q., Desprat, R., Fu, H., Olivier, E., Lin, C.M., Lobell, A., Gowda, S.N., Aladjem, M.I., Bouhasira, E.E., 2006. DNA methylation supports intrinsic epigenetic memory in mammalian cells. PLOS Genet. 2, 0461-0470], using a transgenic experimental system, indicates that these marks may be acquired in more than one order and thus, silent heterochromatic structure can be initiated by either methylation of CpG dinucleotides or by histone modifications. In this system, however, CpG methylation appears to differ from histone modifications because it bestows a persistent epigenetic, or cellular, memory. In other words, CpG methylation can independently confer cellular memory, whereas histone modifications appear to be limited in this capacity. Therefore, in the context of genomic reprogramming induced by SCNT, efficient demethylation is likely a key (if not the only) rate-limiting step to improving the efficiency and outcomes of SCNT cloning. This review discusses the possibility of targeting cellular memory, and in particular inducing demethylation of a somatic nucleus prior to nuclear transfer, to enable reprogramming events typically carried out by oocyte factors and thereby improve developmental competence of SCNT-reconstructed embryos. Several recent published reviews of SCNT, cellular reprogramming and genomic demethylation served as valuable sources for the authors and are recommended as supplemental reading. These include the following: Bird, A., 2002. DNA methylation patterns and epigenetic memory. Gen. Dev. 16, 6-21; Grafi, G., 2004. How cells dedifferentiate: a lesson from plants. Dev. Biol. 268, 1-6; Latham, K.E., 2005. Early and delayed aspects of nuclear reprogramming during cloning. Biol. Cell 97, 119-132; Lyko, F., Brown, R., 2005. DNA methyltransferase inhibitors and the development of epigenetic cancer therapies. J.Natl. Cancer Inst. 97, 1498-1506; Morgan, H.D., Santos, F., Green, K., Dean, W., Reik, W., 2005. Epigenetic reprogramming in mammals. Hum. Mol. Gen. 14, R47-R58; Szyf, M., 2005. DNA methylation and demethylation as targets for anticancer therapy. Biochemistry 70, 533-549; Buszczak, M., Spradling, A.C., 2006. Searching chromatin for stem cell identity. Cell 125, 233-236; Gurdon, J.B., 2006. From nuclear transfer to nuclear reprogramming: the reversal of cell differentiation. Annu. Rev. Cell. Dev. Biol. 22, 1-22; Yoo, C.B., Jones, P.A., 2006. Epigenetic therapy of cancer: past, present and future. Nat. Rev. 5, 37-50." @default.
• W2079181573 created "2016-06-24" @default.
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• W2079181573 date "2007-03-01" @default.
• W2079181573 modified "2023-10-14" @default.
• W2079181573 title "Targeting cellular memory to reprogram the epigenome, restore potential, and improve somatic cell nuclear transfer" @default.
• W2079181573 cites W1486257535 @default.
• W2079181573 cites W1488195106 @default.
• W2079181573 cites W1548746280 @default.
• W2079181573 cites W1557154008 @default.
• W2079181573 cites W1622356789 @default.
• W2079181573 cites W1637312052 @default.
• W2079181573 cites W1673514954 @default.
• W2079181573 cites W1784857457 @default.
• W2079181573 cites W1855977133 @default.
• W2079181573 cites W1907843957 @default.
• W2079181573 cites W1965433891 @default.
• W2079181573 cites W1966202256 @default.
• W2079181573 cites W1971400148 @default.
• W2079181573 cites W1978287692 @default.
• W2079181573 cites W1989676756 @default.
• W2079181573 cites W1991512401 @default.
• W2079181573 cites W1996339364 @default.
• W2079181573 cites W2001531875 @default.
• W2079181573 cites W2002698073 @default.
• W2079181573 cites W2006594553 @default.
• W2079181573 cites W2006717587 @default.
• W2079181573 cites W2006788765 @default.
• W2079181573 cites W2009121506 @default.
• W2079181573 cites W2013154874 @default.
• W2079181573 cites W2015132841 @default.
• W2079181573 cites W2016477435 @default.
• W2079181573 cites W2016696563 @default.
• W2079181573 cites W2020170592 @default.
• W2079181573 cites W2026963278 @default.
• W2079181573 cites W2027117363 @default.
• W2079181573 cites W2034682317 @default.
• W2079181573 cites W2042911394 @default.
• W2079181573 cites W2046516893 @default.
• W2079181573 cites W2047143392 @default.
• W2079181573 cites W2050419632 @default.
• W2079181573 cites W2052665087 @default.
• W2079181573 cites W2053421436 @default.
• W2079181573 cites W2055171335 @default.
• W2079181573 cites W2059223797 @default.
• W2079181573 cites W2059696301 @default.
• W2079181573 cites W2059950394 @default.
• W2079181573 cites W2063073228 @default.
• W2079181573 cites W2064268598 @default.
• W2079181573 cites W2065195395 @default.
• W2079181573 cites W2067423804 @default.
• W2079181573 cites W2071953998 @default.
• W2079181573 cites W2075087486 @default.
• W2079181573 cites W2075684759 @default.
• W2079181573 cites W2076005660 @default.
• W2079181573 cites W2077053535 @default.
• W2079181573 cites W2078832003 @default.
• W2079181573 cites W2084017377 @default.
• W2079181573 cites W2085753491 @default.
• W2079181573 cites W2087074879 @default.
• W2079181573 cites W2087172939 @default.
• W2079181573 cites W2091602444 @default.
• W2079181573 cites W2091677482 @default.
• W2079181573 cites W2093155802 @default.
• W2079181573 cites W2096534598 @default.
• W2079181573 cites W2097459238 @default.
• W2079181573 cites W2098170273 @default.
• W2079181573 cites W2100302916 @default.
• W2079181573 cites W2106715610 @default.
• W2079181573 cites W2107257929 @default.
• W2079181573 cites W2111709760 @default.
• W2079181573 cites W2114599216 @default.
• W2079181573 cites W2114758163 @default.
• W2079181573 cites W2118681186 @default.
• W2079181573 cites W2121417064 @default.
• W2079181573 cites W2124049725 @default.
• W2079181573 cites W2127403356 @default.
• W2079181573 cites W2127431151 @default.
• W2079181573 cites W2127884678 @default.
• W2079181573 cites W2132798049 @default.
• W2079181573 cites W2133067519 @default.
• W2079181573 cites W2137445724 @default.
• W2079181573 cites W2137477400 @default.
• W2079181573 cites W2142749576 @default.
• W2079181573 cites W2143658931 @default.
• W2079181573 cites W2145337538 @default.
• W2079181573 cites W2145750252 @default.
• W2079181573 cites W2148660548 @default.
• W2079181573 cites W2148800819 @default.
• W2079181573 cites W2149790281 @default.
• W2079181573 cites W2150733697 @default.
• W2079181573 cites W2153900602 @default.
• W2079181573 cites W2153961184 @default.
• W2079181573 cites W2154284135 @default.
• W2079181573 cites W2163710445 @default.

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