Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079183057> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2079183057 endingPage "26" @default.
- W2079183057 startingPage "21" @default.
- W2079183057 abstract "A set of stable nitroxide free radicals that are used as spin labels have been shown to possess metal-independent superoxide dismutase-like activity. Unlike superoxide dismutase (SOD), these compounds are low molecular weight, and readily penetrate into the cell. A representative nitroxide, 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy (Tempol), was investigated for antimutagenic activity in the XPRT forward mutation assay in CHO AS52 cells. AS52 cells were exposed to hydrogen peroxide, or the hypoxanthine/xanthine oxidase superoxide generating system, in the presence or absence of 10 mM Tempol. Tempol itself was not mutagenic or toxic to AS52 cells. Tempol protected cells nearly completely from the cytotoxic and mutagenic effects of hydrogen peroxide and hypoxanthine/xanthine oxidase. We have previously shown that nitroxides do not alter the extracellular concentration of hydrogen peroxide, and that they are taken up by mammalian cells, suggesting that the antimutagenic activity of Tempol is an intracellular phenomenon." @default.
- W2079183057 created "2016-06-24" @default.
- W2079183057 creator A5000621452 @default.
- W2079183057 creator A5014699467 @default.
- W2079183057 creator A5072939048 @default.
- W2079183057 creator A5081250782 @default.
- W2079183057 date "1992-01-01" @default.
- W2079183057 modified "2023-09-25" @default.
- W2079183057 title "Antimutagenicity of a low molecular weight superoxide dismutase mimic against oxidative mutagens" @default.
- W2079183057 cites W1538731517 @default.
- W2079183057 cites W1772905558 @default.
- W2079183057 cites W1984583542 @default.
- W2079183057 cites W1985915773 @default.
- W2079183057 cites W1993192939 @default.
- W2079183057 cites W1993257224 @default.
- W2079183057 cites W1998596519 @default.
- W2079183057 cites W2009955537 @default.
- W2079183057 cites W2013105195 @default.
- W2079183057 cites W2036999667 @default.
- W2079183057 cites W2042582442 @default.
- W2079183057 cites W2043612650 @default.
- W2079183057 cites W2047034210 @default.
- W2079183057 cites W2048765702 @default.
- W2079183057 cites W2067975042 @default.
- W2079183057 cites W2072210093 @default.
- W2079183057 cites W2104145747 @default.
- W2079183057 cites W2126370064 @default.
- W2079183057 cites W2149137963 @default.
- W2079183057 cites W2290838718 @default.
- W2079183057 doi "https://doi.org/10.1002/em.2850190105" @default.
- W2079183057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1310080" @default.
- W2079183057 hasPublicationYear "1992" @default.
- W2079183057 type Work @default.
- W2079183057 sameAs 2079183057 @default.
- W2079183057 citedByCount "47" @default.
- W2079183057 countsByYear W20791830572012 @default.
- W2079183057 countsByYear W20791830572014 @default.
- W2079183057 countsByYear W20791830572015 @default.
- W2079183057 countsByYear W20791830572018 @default.
- W2079183057 countsByYear W20791830572021 @default.
- W2079183057 crossrefType "journal-article" @default.
- W2079183057 hasAuthorship W2079183057A5000621452 @default.
- W2079183057 hasAuthorship W2079183057A5014699467 @default.
- W2079183057 hasAuthorship W2079183057A5072939048 @default.
- W2079183057 hasAuthorship W2079183057A5081250782 @default.
- W2079183057 hasConcept C139066938 @default.
- W2079183057 hasConcept C181199279 @default.
- W2079183057 hasConcept C185592680 @default.
- W2079183057 hasConcept C2775838275 @default.
- W2079183057 hasConcept C2778004101 @default.
- W2079183057 hasConcept C2778102346 @default.
- W2079183057 hasConcept C2779470414 @default.
- W2079183057 hasConcept C2780795997 @default.
- W2079183057 hasConcept C2781116151 @default.
- W2079183057 hasConcept C48349386 @default.
- W2079183057 hasConcept C533411734 @default.
- W2079183057 hasConcept C55493867 @default.
- W2079183057 hasConcept C57600042 @default.
- W2079183057 hasConceptScore W2079183057C139066938 @default.
- W2079183057 hasConceptScore W2079183057C181199279 @default.
- W2079183057 hasConceptScore W2079183057C185592680 @default.
- W2079183057 hasConceptScore W2079183057C2775838275 @default.
- W2079183057 hasConceptScore W2079183057C2778004101 @default.
- W2079183057 hasConceptScore W2079183057C2778102346 @default.
- W2079183057 hasConceptScore W2079183057C2779470414 @default.
- W2079183057 hasConceptScore W2079183057C2780795997 @default.
- W2079183057 hasConceptScore W2079183057C2781116151 @default.
- W2079183057 hasConceptScore W2079183057C48349386 @default.
- W2079183057 hasConceptScore W2079183057C533411734 @default.
- W2079183057 hasConceptScore W2079183057C55493867 @default.
- W2079183057 hasConceptScore W2079183057C57600042 @default.
- W2079183057 hasIssue "1" @default.
- W2079183057 hasLocation W20791830571 @default.
- W2079183057 hasLocation W20791830572 @default.
- W2079183057 hasOpenAccess W2079183057 @default.
- W2079183057 hasPrimaryLocation W20791830571 @default.
- W2079183057 hasRelatedWork W183295734 @default.
- W2079183057 hasRelatedWork W200540328 @default.
- W2079183057 hasRelatedWork W2022144402 @default.
- W2079183057 hasRelatedWork W2029575885 @default.
- W2079183057 hasRelatedWork W2275412511 @default.
- W2079183057 hasRelatedWork W2489465171 @default.
- W2079183057 hasRelatedWork W3150818306 @default.
- W2079183057 hasRelatedWork W4235615426 @default.
- W2079183057 hasRelatedWork W4244932118 @default.
- W2079183057 hasRelatedWork W2185303347 @default.
- W2079183057 hasVolume "19" @default.
- W2079183057 isParatext "false" @default.
- W2079183057 isRetracted "false" @default.
- W2079183057 magId "2079183057" @default.
- W2079183057 workType "article" @default.