Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079183347> ?p ?o ?g. }
- W2079183347 endingPage "50" @default.
- W2079183347 startingPage "41" @default.
- W2079183347 abstract "Objectives: Increased iron deposition in the brain may occur in several neurodegenerative diseases, including Alzheimer disease (AD). Iron deposits shorten T2 relaxation times on T2-weighted magnetic resonance (MR) images. Iron-dependent contrast increases with magnetic field strength. We hypothesized that T2 mapping using 3 T MR imaging (MRI) can disclose differences between normal controls and AD subjects. Methods: High-resolution brain imaging protocols were developed and applied to 24 AD patients and 20 age-matched controls using 3 T MRI. Eight anatomical regions of interest were manually segmented, and T2 histograms were computed. A visual analysis technique, the heat map, was modified and applied to the large image data sets generated by these protocols. Results: A large number (163) of features from these histograms were examined, and 38 of these were significantly different (P < 0.05) between the groups. In the hippocampus, evidence was found for AD-related increases in iron deposition (shortened T2) and in the concentration of free tissue water (lengthened T2). Imaging of a section of postmortem brain before and after chemically extracting the iron established the presence of MRI-detectable iron in the hippocampus, cortex, and white matter in addition to brain regions traditionally viewed as containing high iron concentrations." @default.
- W2079183347 created "2016-06-24" @default.
- W2079183347 creator A5001826603 @default.
- W2079183347 creator A5022187043 @default.
- W2079183347 creator A5024675987 @default.
- W2079183347 creator A5037662570 @default.
- W2079183347 creator A5038837596 @default.
- W2079183347 creator A5040058580 @default.
- W2079183347 creator A5050913328 @default.
- W2079183347 creator A5051789719 @default.
- W2079183347 creator A5065894311 @default.
- W2079183347 creator A5079272830 @default.
- W2079183347 creator A5079983978 @default.
- W2079183347 creator A5081741619 @default.
- W2079183347 creator A5084448351 @default.
- W2079183347 date "2006-02-01" @default.
- W2079183347 modified "2023-09-23" @default.
- W2079183347 title "High-field Magnetic Resonance Imaging of Brain Iron in Alzheimer Disease" @default.
- W2079183347 cites W1488034034 @default.
- W2079183347 cites W1538748480 @default.
- W2079183347 cites W1967922486 @default.
- W2079183347 cites W1970452111 @default.
- W2079183347 cites W1971368621 @default.
- W2079183347 cites W1973077436 @default.
- W2079183347 cites W1973462954 @default.
- W2079183347 cites W1978340256 @default.
- W2079183347 cites W1978831666 @default.
- W2079183347 cites W1980806973 @default.
- W2079183347 cites W1981835221 @default.
- W2079183347 cites W1986318523 @default.
- W2079183347 cites W1991500873 @default.
- W2079183347 cites W1991717828 @default.
- W2079183347 cites W2005133023 @default.
- W2079183347 cites W2005729509 @default.
- W2079183347 cites W2013136731 @default.
- W2079183347 cites W2014155195 @default.
- W2079183347 cites W2016731602 @default.
- W2079183347 cites W2024443281 @default.
- W2079183347 cites W2027189256 @default.
- W2079183347 cites W2031433969 @default.
- W2079183347 cites W2033317847 @default.
- W2079183347 cites W2037248080 @default.
- W2079183347 cites W2042631521 @default.
- W2079183347 cites W2043541600 @default.
- W2079183347 cites W2043781970 @default.
- W2079183347 cites W2046596211 @default.
- W2079183347 cites W2058448983 @default.
- W2079183347 cites W2059081843 @default.
- W2079183347 cites W2062065994 @default.
- W2079183347 cites W2063136428 @default.
- W2079183347 cites W2063477088 @default.
- W2079183347 cites W2065854466 @default.
- W2079183347 cites W2069853638 @default.
- W2079183347 cites W2072846848 @default.
- W2079183347 cites W2073073420 @default.
- W2079183347 cites W2074827177 @default.
- W2079183347 cites W2075975601 @default.
- W2079183347 cites W2076182555 @default.
- W2079183347 cites W2077047572 @default.
- W2079183347 cites W2077880605 @default.
- W2079183347 cites W2079822311 @default.
- W2079183347 cites W2083715632 @default.
- W2079183347 cites W2084548038 @default.
- W2079183347 cites W2085842761 @default.
- W2079183347 cites W2090977462 @default.
- W2079183347 cites W2095431003 @default.
- W2079183347 cites W2101855054 @default.
- W2079183347 cites W2102239505 @default.
- W2079183347 cites W2104382764 @default.
- W2079183347 cites W2105141004 @default.
- W2079183347 cites W2106212803 @default.
- W2079183347 cites W2109845730 @default.
- W2079183347 cites W2112587738 @default.
- W2079183347 cites W2117140276 @default.
- W2079183347 cites W2117623631 @default.
- W2079183347 cites W2121597504 @default.
- W2079183347 cites W2124114508 @default.
- W2079183347 cites W2128540699 @default.
- W2079183347 cites W2133324295 @default.
- W2079183347 cites W2135501308 @default.
- W2079183347 cites W2137122576 @default.
- W2079183347 cites W2141150496 @default.
- W2079183347 cites W2146336531 @default.
- W2079183347 cites W2150926065 @default.
- W2079183347 cites W2152058429 @default.
- W2079183347 cites W2152276235 @default.
- W2079183347 cites W2155045673 @default.
- W2079183347 cites W2155299988 @default.
- W2079183347 cites W2155492919 @default.
- W2079183347 cites W2156220037 @default.
- W2079183347 cites W2158024705 @default.
- W2079183347 cites W2160027020 @default.
- W2079183347 cites W2160636151 @default.
- W2079183347 cites W2161144725 @default.
- W2079183347 cites W2161153660 @default.
- W2079183347 cites W2162319029 @default.
- W2079183347 cites W2167720733 @default.
- W2079183347 cites W2172296443 @default.