Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079183433> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2079183433 endingPage "629" @default.
- W2079183433 startingPage "625" @default.
- W2079183433 abstract "1 Free radical-induced lipid peroxidation and changes in protein and nucleic acid structures can result in various human ailments, including ageing, neurodegenerative disorders and cancer. High body fat or dietary fat further enhances the free radical-mediated pathogenesis of various diseases. 2 In the present study, the in vitro anti-oxidant and DNA protective effects of the novel cardiovascular drug rosuvastatin were evaluated. Anti-oxidant activity was evaluated on the basis of inhibition of lipid peroxidation, scavenging of superoxide radical and the reduction of ferric ions (Fe3+). Inhibition of lipid peroxidation was determined using Fenton's reaction-induced lipid peroxidation in rat liver and brain homogenates and liver mitochondria. Superoxide radical-scavenging activity was evaluated by scavenging of the superoxide anion generated by photo illumination of riboflavin and Fe3+-reducing activity was determined by the ferric-reducing anti-oxidant power (FRAP) assay. DNA protection was evaluated according to changes in H2O2-induced pBR322 plasmid DNA and Fenton's reaction-induced-fragmentation of rat liver DNA. 3 The results indicate that rosuvastatin (1.5 or 2 mg/mL) is able to protect against lipid peroxidation. Furthermore, H2O2-induced changes in pBR322 plasmid DNA and fragmentation of hepatic DNA were alleviated by rosuvastatin. However, rosuvastatin did not show any superoxide anion-scavenging activity. The protective mechanism of rosuvastatin can be correlated with the reducing equivalent donating property or direct hydroxyl radical-scavenging activity of the drug. 4 The pleiotropic activities of rosuvastatin exhibited suggest its clinical advantages against oxidative stress-induced human ailments in addition to its widely using hypolipidaemic effect." @default.
- W2079183433 created "2016-06-24" @default.
- W2079183433 creator A5061478744 @default.
- W2079183433 creator A5075641059 @default.
- W2079183433 creator A5085203627 @default.
- W2079183433 date "2007-12-26" @default.
- W2079183433 modified "2023-10-16" @default.
- W2079183433 title "<i>IN VITRO </i>ANTI‐OXIDANT AND DNA PROTECTIVE EFFECTS OF THE NOVEL 3‐HYDROXY‐3‐METHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR ROSUVASTATIN" @default.
- W2079183433 cites W1662660456 @default.
- W2079183433 cites W1968014927 @default.
- W2079183433 cites W1976749186 @default.
- W2079183433 cites W1982870743 @default.
- W2079183433 cites W1983310681 @default.
- W2079183433 cites W2002518891 @default.
- W2079183433 cites W2007129673 @default.
- W2079183433 cites W2007285256 @default.
- W2079183433 cites W2011951281 @default.
- W2079183433 cites W2013642556 @default.
- W2079183433 cites W2027262563 @default.
- W2079183433 cites W2027651810 @default.
- W2079183433 cites W2028585334 @default.
- W2079183433 cites W2030253897 @default.
- W2079183433 cites W2031379379 @default.
- W2079183433 cites W2038338711 @default.
- W2079183433 cites W2038434900 @default.
- W2079183433 cites W2045986346 @default.
- W2079183433 cites W2047614548 @default.
- W2079183433 cites W2063313335 @default.
- W2079183433 cites W2070013537 @default.
- W2079183433 cites W2076346268 @default.
- W2079183433 cites W2084648638 @default.
- W2079183433 cites W2094353481 @default.
- W2079183433 cites W2110075772 @default.
- W2079183433 cites W2131461587 @default.
- W2079183433 cites W2140126848 @default.
- W2079183433 cites W2164613158 @default.
- W2079183433 cites W2167693380 @default.
- W2079183433 doi "https://doi.org/10.1111/j.1440-1681.2007.04853.x" @default.
- W2079183433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18177480" @default.
- W2079183433 hasPublicationYear "2007" @default.
- W2079183433 type Work @default.
- W2079183433 sameAs 2079183433 @default.
- W2079183433 citedByCount "31" @default.
- W2079183433 countsByYear W20791834332012 @default.
- W2079183433 countsByYear W20791834332013 @default.
- W2079183433 countsByYear W20791834332014 @default.
- W2079183433 countsByYear W20791834332015 @default.
- W2079183433 countsByYear W20791834332016 @default.
- W2079183433 countsByYear W20791834332017 @default.
- W2079183433 countsByYear W20791834332018 @default.
- W2079183433 countsByYear W20791834332019 @default.
- W2079183433 countsByYear W20791834332021 @default.
- W2079183433 crossrefType "journal-article" @default.
- W2079183433 hasAuthorship W2079183433A5061478744 @default.
- W2079183433 hasAuthorship W2079183433A5075641059 @default.
- W2079183433 hasAuthorship W2079183433A5085203627 @default.
- W2079183433 hasConcept C181199279 @default.
- W2079183433 hasConcept C185592680 @default.
- W2079183433 hasConcept C2776151105 @default.
- W2079183433 hasConcept C2776778087 @default.
- W2079183433 hasConcept C2778004101 @default.
- W2079183433 hasConcept C2780499067 @default.
- W2079183433 hasConcept C2780795997 @default.
- W2079183433 hasConcept C2780829032 @default.
- W2079183433 hasConcept C55493867 @default.
- W2079183433 hasConcept C86803240 @default.
- W2079183433 hasConcept C98274493 @default.
- W2079183433 hasConceptScore W2079183433C181199279 @default.
- W2079183433 hasConceptScore W2079183433C185592680 @default.
- W2079183433 hasConceptScore W2079183433C2776151105 @default.
- W2079183433 hasConceptScore W2079183433C2776778087 @default.
- W2079183433 hasConceptScore W2079183433C2778004101 @default.
- W2079183433 hasConceptScore W2079183433C2780499067 @default.
- W2079183433 hasConceptScore W2079183433C2780795997 @default.
- W2079183433 hasConceptScore W2079183433C2780829032 @default.
- W2079183433 hasConceptScore W2079183433C55493867 @default.
- W2079183433 hasConceptScore W2079183433C86803240 @default.
- W2079183433 hasConceptScore W2079183433C98274493 @default.
- W2079183433 hasIssue "5-6" @default.
- W2079183433 hasLocation W20791834331 @default.
- W2079183433 hasLocation W20791834332 @default.
- W2079183433 hasOpenAccess W2079183433 @default.
- W2079183433 hasPrimaryLocation W20791834331 @default.
- W2079183433 hasRelatedWork W1470000624 @default.
- W2079183433 hasRelatedWork W1977480715 @default.
- W2079183433 hasRelatedWork W2079183433 @default.
- W2079183433 hasRelatedWork W2090030253 @default.
- W2079183433 hasRelatedWork W2200058491 @default.
- W2079183433 hasRelatedWork W2364950704 @default.
- W2079183433 hasRelatedWork W2382076036 @default.
- W2079183433 hasRelatedWork W2390491189 @default.
- W2079183433 hasRelatedWork W2390901261 @default.
- W2079183433 hasRelatedWork W2884957776 @default.
- W2079183433 hasVolume "35" @default.
- W2079183433 isParatext "false" @default.
- W2079183433 isRetracted "false" @default.
- W2079183433 magId "2079183433" @default.
- W2079183433 workType "article" @default.