Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079183971> ?p ?o ?g. }
- W2079183971 endingPage "671" @default.
- W2079183971 startingPage "662" @default.
- W2079183971 abstract "Interactions between the microbiota and distal gut are fundamental determinants of human health. Such interactions are concentrated at the colonic mucosa and provide energy for the host epithelium through the production of the short-chain fatty acid butyrate. We sought to determine the role of epithelial butyrate metabolism in establishing the austere oxygenation profile of the distal gut. Bacteria-derived butyrate affects epithelial O2 consumption and results in stabilization of hypoxia-inducible factor (HIF), a transcription factor coordinating barrier protection. Antibiotic-mediated depletion of the microbiota reduces colonic butyrate and HIF expression, both of which are restored by butyrate supplementation. Additionally, germ-free mice exhibit diminished retention of O2-sensitive dyes and decreased stabilized HIF. Furthermore, the influences of butyrate are lost in cells lacking HIF, thus linking butyrate metabolism to stabilized HIF and barrier function. This work highlights a mechanism where host-microbe interactions augment barrier function in the distal gut." @default.
- W2079183971 created "2016-06-24" @default.
- W2079183971 creator A5007636344 @default.
- W2079183971 creator A5007816191 @default.
- W2079183971 creator A5007850731 @default.
- W2079183971 creator A5015115989 @default.
- W2079183971 creator A5027233017 @default.
- W2079183971 creator A5027247346 @default.
- W2079183971 creator A5034128223 @default.
- W2079183971 creator A5049650132 @default.
- W2079183971 creator A5051618208 @default.
- W2079183971 creator A5052166300 @default.
- W2079183971 creator A5057952110 @default.
- W2079183971 creator A5062002701 @default.
- W2079183971 creator A5065109449 @default.
- W2079183971 creator A5065279844 @default.
- W2079183971 creator A5067693788 @default.
- W2079183971 creator A5080408249 @default.
- W2079183971 creator A5087143086 @default.
- W2079183971 creator A5090798159 @default.
- W2079183971 date "2015-05-01" @default.
- W2079183971 modified "2023-10-18" @default.
- W2079183971 title "Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function" @default.
- W2079183971 cites W1480951384 @default.
- W2079183971 cites W1934624334 @default.
- W2079183971 cites W1966798186 @default.
- W2079183971 cites W1970971661 @default.
- W2079183971 cites W1992933063 @default.
- W2079183971 cites W1994687037 @default.
- W2079183971 cites W2003976217 @default.
- W2079183971 cites W2014379712 @default.
- W2079183971 cites W2018008610 @default.
- W2079183971 cites W2018782206 @default.
- W2079183971 cites W2018861313 @default.
- W2079183971 cites W2019683289 @default.
- W2079183971 cites W2020205872 @default.
- W2079183971 cites W2028520715 @default.
- W2079183971 cites W2034997979 @default.
- W2079183971 cites W2036059068 @default.
- W2079183971 cites W2056425530 @default.
- W2079183971 cites W2066159720 @default.
- W2079183971 cites W2067659428 @default.
- W2079183971 cites W2070930785 @default.
- W2079183971 cites W2071825506 @default.
- W2079183971 cites W2078703212 @default.
- W2079183971 cites W2082578477 @default.
- W2079183971 cites W2083096979 @default.
- W2079183971 cites W2085100595 @default.
- W2079183971 cites W2089187598 @default.
- W2079183971 cites W2095863342 @default.
- W2079183971 cites W2098087741 @default.
- W2079183971 cites W2108780695 @default.
- W2079183971 cites W2115450300 @default.
- W2079183971 cites W2116846792 @default.
- W2079183971 cites W2121498342 @default.
- W2079183971 cites W2122637273 @default.
- W2079183971 cites W2125229121 @default.
- W2079183971 cites W2128992702 @default.
- W2079183971 cites W2133293185 @default.
- W2079183971 cites W2133938746 @default.
- W2079183971 cites W2153538626 @default.
- W2079183971 cites W2162133321 @default.
- W2079183971 cites W2166691283 @default.
- W2079183971 cites W2174912594 @default.
- W2079183971 cites W2321654132 @default.
- W2079183971 cites W4234288885 @default.
- W2079183971 doi "https://doi.org/10.1016/j.chom.2015.03.005" @default.
- W2079183971 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4433427" @default.
- W2079183971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25865369" @default.
- W2079183971 hasPublicationYear "2015" @default.
- W2079183971 type Work @default.
- W2079183971 sameAs 2079183971 @default.
- W2079183971 citedByCount "1035" @default.
- W2079183971 countsByYear W20791839712015 @default.
- W2079183971 countsByYear W20791839712016 @default.
- W2079183971 countsByYear W20791839712017 @default.
- W2079183971 countsByYear W20791839712018 @default.
- W2079183971 countsByYear W20791839712019 @default.
- W2079183971 countsByYear W20791839712020 @default.
- W2079183971 countsByYear W20791839712021 @default.
- W2079183971 countsByYear W20791839712022 @default.
- W2079183971 countsByYear W20791839712023 @default.
- W2079183971 crossrefType "journal-article" @default.
- W2079183971 hasAuthorship W2079183971A5007636344 @default.
- W2079183971 hasAuthorship W2079183971A5007816191 @default.
- W2079183971 hasAuthorship W2079183971A5007850731 @default.
- W2079183971 hasAuthorship W2079183971A5015115989 @default.
- W2079183971 hasAuthorship W2079183971A5027233017 @default.
- W2079183971 hasAuthorship W2079183971A5027247346 @default.
- W2079183971 hasAuthorship W2079183971A5034128223 @default.
- W2079183971 hasAuthorship W2079183971A5049650132 @default.
- W2079183971 hasAuthorship W2079183971A5051618208 @default.
- W2079183971 hasAuthorship W2079183971A5052166300 @default.
- W2079183971 hasAuthorship W2079183971A5057952110 @default.
- W2079183971 hasAuthorship W2079183971A5062002701 @default.
- W2079183971 hasAuthorship W2079183971A5065109449 @default.
- W2079183971 hasAuthorship W2079183971A5065279844 @default.
- W2079183971 hasAuthorship W2079183971A5067693788 @default.