FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079184110> ?p ?o ?g. }

• W2079184110 endingPage "1180" @default.
• W2079184110 startingPage "1168" @default.
• W2079184110 abstract "This free-flow micropuncture study examined the dependence of bicarbonate reabsorption in the rat superficial proximal convoluted tubule to changes in filtered bicarbonate load, and thereby the contribution of the proximal tubule to the whole kidney's response to such changes. The independent effects of extracellular fluid (ECF) volume expansion and of acidosis on proximal bicarbonate reabsorption were also examined. When the plasma volume contraction incurred by the micropuncture preparatory surgery was corrected by isoncotic plasma infusion ( congruent with1.3% body wt), single nephron glomerular filtration rate (SNGFR), and the filtered total CO(2) load increased by 50%. Absolute proximal reabsorption of total CO(2) (measured by microcalorimetry) increased by 30%, from 808+/-47 during volume contraction to 1,081+/-57 pmol/min.g kidney wt after plasma repletion, as fractional total CO(2) reabsorption decreased from 0.90 to 0.77. Aortic constriction in these plasma-repleted rats returned the filtered load and reabsorption of total CO(2) to the previous volume contracted levels. In other animals isohydric ECF expansion with plasma (5% body wt) or Ringer's solution (10% body wt), or both, produced no further diminution in fractional proximal total CO(2) reabsorption (0.76-0.81). Metabolic acidosis was associated with very high fractional proximal total CO(2) reabsorptive rates of 0.82 to 0.91 over a wide range of SNGFR and ECF volumes. At a single level of SNGFR, end-proximal total CO(2) concentration progressively decreased from 5.6+/-0.5 to 1.6 +/-0.2 mM as arterial pH fell from 7.4 to 7.1. Expansion of ECF volume in the acidotic rats did not inhibit the ability of the proximal tubule to lower end-proximal total CO(2) concentrations to minimal levels. In conclusion, bicarbonate reabsorption in the superficial proximal convoluted tubule is highly load-dependent (75-90%) in normal and acidotic rats. No inhibitory effect of ECF volume per se on proximal bicarbonate reabsorption, independent of altering the filtered bicarbonate load, could be discerned. Acidosis enabled the end-proximal luminal bicarbonate concentration to fall below normal values and reduced distal bicarbonate delivery." @default.
• W2079184110 created "2016-06-24" @default.
• W2079184110 creator A5016244444 @default.
• W2079184110 creator A5018130322 @default.
• W2079184110 creator A5021253956 @default.
• W2079184110 creator A5035468122 @default.
• W2079184110 creator A5062105540 @default.
• W2079184110 creator A5085308575 @default.
• W2079184110 date "1979-11-01" @default.
• W2079184110 modified "2023-10-15" @default.
• W2079184110 title "Control of Proximal Bicarbonate Reabsorption in Normal and Acidotic Rats" @default.
• W2079184110 cites W1977205236 @default.
• W2079184110 cites W1985812410 @default.
• W2079184110 cites W1996594976 @default.
• W2079184110 cites W2000717752 @default.
• W2079184110 cites W2008751584 @default.
• W2079184110 cites W2010752164 @default.
• W2079184110 cites W2017969703 @default.
• W2079184110 cites W2035301599 @default.
• W2079184110 cites W2051215995 @default.
• W2079184110 cites W2055876808 @default.
• W2079184110 cites W2071325348 @default.
• W2079184110 cites W2083556057 @default.
• W2079184110 cites W2114828050 @default.
• W2079184110 cites W2124878379 @default.
• W2079184110 cites W2128103934 @default.
• W2079184110 cites W2131239099 @default.
• W2079184110 cites W2206459557 @default.
• W2079184110 cites W2208417929 @default.
• W2079184110 cites W2229495751 @default.
• W2079184110 cites W2283280951 @default.
• W2079184110 cites W2315893894 @default.
• W2079184110 cites W2403854246 @default.
• W2079184110 cites W2409638642 @default.
• W2079184110 cites W2413049951 @default.
• W2079184110 cites W2416946018 @default.
• W2079184110 cites W2417513530 @default.
• W2079184110 cites W2419245085 @default.
• W2079184110 cites W2463978697 @default.
• W2079184110 cites W2464484584 @default.
• W2079184110 cites W2465778866 @default.
• W2079184110 cites W2471087447 @default.
• W2079184110 cites W2474633938 @default.
• W2079184110 cites W2606557174 @default.
• W2079184110 cites W2943435830 @default.
• W2079184110 doi "https://doi.org/10.1172/jci109570" @default.
• W2079184110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/371261" @default.
• W2079184110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/500804" @default.
• W2079184110 hasPublicationYear "1979" @default.
• W2079184110 type Work @default.
• W2079184110 sameAs 2079184110 @default.
• W2079184110 citedByCount "70" @default.
• W2079184110 countsByYear W20791841102012 @default.
• W2079184110 countsByYear W20791841102013 @default.
• W2079184110 countsByYear W20791841102014 @default.
• W2079184110 countsByYear W20791841102016 @default.
• W2079184110 countsByYear W20791841102021 @default.
• W2079184110 countsByYear W20791841102023 @default.
• W2079184110 crossrefType "journal-article" @default.
• W2079184110 hasAuthorship W2079184110A5016244444 @default.
• W2079184110 hasAuthorship W2079184110A5018130322 @default.
• W2079184110 hasAuthorship W2079184110A5021253956 @default.
• W2079184110 hasAuthorship W2079184110A5035468122 @default.
• W2079184110 hasAuthorship W2079184110A5062105540 @default.
• W2079184110 hasAuthorship W2079184110A5085308575 @default.
• W2079184110 hasBestOaLocation W20791841101 @default.
• W2079184110 hasConcept C126322002 @default.
• W2079184110 hasConcept C134018914 @default.
• W2079184110 hasConcept C159641895 @default.
• W2079184110 hasConcept C185592680 @default.
• W2079184110 hasConcept C2113261 @default.
• W2079184110 hasConcept C2778553927 @default.
• W2079184110 hasConcept C2779010597 @default.
• W2079184110 hasConcept C2779246250 @default.
• W2079184110 hasConcept C2780091579 @default.
• W2079184110 hasConcept C2781112554 @default.
• W2079184110 hasConcept C2781231759 @default.
• W2079184110 hasConcept C28406088 @default.
• W2079184110 hasConcept C55493867 @default.
• W2079184110 hasConcept C56906281 @default.
• W2079184110 hasConcept C71924100 @default.
• W2079184110 hasConcept C86803240 @default.
• W2079184110 hasConceptScore W2079184110C126322002 @default.
• W2079184110 hasConceptScore W2079184110C134018914 @default.
• W2079184110 hasConceptScore W2079184110C159641895 @default.
• W2079184110 hasConceptScore W2079184110C185592680 @default.
• W2079184110 hasConceptScore W2079184110C2113261 @default.
• W2079184110 hasConceptScore W2079184110C2778553927 @default.
• W2079184110 hasConceptScore W2079184110C2779010597 @default.
• W2079184110 hasConceptScore W2079184110C2779246250 @default.
• W2079184110 hasConceptScore W2079184110C2780091579 @default.
• W2079184110 hasConceptScore W2079184110C2781112554 @default.
• W2079184110 hasConceptScore W2079184110C2781231759 @default.
• W2079184110 hasConceptScore W2079184110C28406088 @default.
• W2079184110 hasConceptScore W2079184110C55493867 @default.
• W2079184110 hasConceptScore W2079184110C56906281 @default.
• W2079184110 hasConceptScore W2079184110C71924100 @default.
• W2079184110 hasConceptScore W2079184110C86803240 @default.

• next