FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079185443> ?p ?o ?g. }

• W2079185443 endingPage "542" @default.
• W2079185443 startingPage "536" @default.
• W2079185443 abstract "Two recent genome-wide association studies of East Asian populations revealed three genetic variants in WDFY4/LRRC18 associated with systemic lupus erythematosus (SLE). To identify the gene contributing to this disease susceptibility, we examined the mRNA expression of WDFY4 and LRRC18 in patients with SLE and healthy controls. WDFY4 was significantly downregulated in SLE patients as compared with controls. We used allelic expression and dual-luciferase assays to identify the functional variant. Transcriptional activity was lower for the rs877819A than -G allele. Electrophoretic mobility shift and supershift assays revealed that the transcription factor Yinyang1 (YY1) binds to rs877819, with lower affinity to the A allele, which explained the reduced transcriptional activity. This effect was further confirmed by YY1 small interfering RNA knockdown, overexpression and chromatin immunoprecipitation experiments. rs877819 in WDFY4 might be the functional site associated with SLE by reduced binding of YY1 and downregulating WDFY4 expression." @default.
• W2079185443 created "2016-06-24" @default.
• W2079185443 creator A5012665298 @default.
• W2079185443 creator A5019765145 @default.
• W2079185443 creator A5024997083 @default.
• W2079185443 creator A5038397694 @default.
• W2079185443 creator A5039335550 @default.
• W2079185443 creator A5045161758 @default.
• W2079185443 creator A5046337750 @default.
• W2079185443 creator A5081127855 @default.
• W2079185443 creator A5084485099 @default.
• W2079185443 creator A5088337739 @default.
• W2079185443 creator A5063021457 @default.
• W2079185443 date "2012-09-13" @default.
• W2079185443 modified "2023-10-18" @default.
• W2079185443 title "An intronic variant associated with systemic lupus erythematosus changes the binding affinity of Yinyang1 to downregulate WDFY4" @default.
• W2079185443 cites W1509314368 @default.
• W2079185443 cites W1644144652 @default.
• W2079185443 cites W1832350141 @default.
• W2079185443 cites W1981756836 @default.
• W2079185443 cites W1985778164 @default.
• W2079185443 cites W2007291093 @default.
• W2079185443 cites W2010160850 @default.
• W2079185443 cites W2011749254 @default.
• W2079185443 cites W2013281032 @default.
• W2079185443 cites W2031580483 @default.
• W2079185443 cites W2039840258 @default.
• W2079185443 cites W2056987325 @default.
• W2079185443 cites W2070527591 @default.
• W2079185443 cites W2073839280 @default.
• W2079185443 cites W2078610240 @default.
• W2079185443 cites W2086938034 @default.
• W2079185443 cites W2127983802 @default.
• W2079185443 cites W2131387438 @default.
• W2079185443 cites W2147086116 @default.
• W2079185443 cites W2155522401 @default.
• W2079185443 doi "https://doi.org/10.1038/gene.2012.33" @default.
• W2079185443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22972472" @default.
• W2079185443 hasPublicationYear "2012" @default.
• W2079185443 type Work @default.
• W2079185443 sameAs 2079185443 @default.
• W2079185443 citedByCount "38" @default.
• W2079185443 countsByYear W20791854432013 @default.
• W2079185443 countsByYear W20791854432014 @default.
• W2079185443 countsByYear W20791854432015 @default.
• W2079185443 countsByYear W20791854432016 @default.
• W2079185443 countsByYear W20791854432017 @default.
• W2079185443 countsByYear W20791854432018 @default.
• W2079185443 countsByYear W20791854432019 @default.
• W2079185443 countsByYear W20791854432020 @default.
• W2079185443 countsByYear W20791854432021 @default.
• W2079185443 countsByYear W20791854432022 @default.
• W2079185443 countsByYear W20791854432023 @default.
• W2079185443 crossrefType "journal-article" @default.
• W2079185443 hasAuthorship W2079185443A5012665298 @default.
• W2079185443 hasAuthorship W2079185443A5019765145 @default.
• W2079185443 hasAuthorship W2079185443A5024997083 @default.
• W2079185443 hasAuthorship W2079185443A5038397694 @default.
• W2079185443 hasAuthorship W2079185443A5039335550 @default.
• W2079185443 hasAuthorship W2079185443A5045161758 @default.
• W2079185443 hasAuthorship W2079185443A5046337750 @default.
• W2079185443 hasAuthorship W2079185443A5063021457 @default.
• W2079185443 hasAuthorship W2079185443A5081127855 @default.
• W2079185443 hasAuthorship W2079185443A5084485099 @default.
• W2079185443 hasAuthorship W2079185443A5088337739 @default.
• W2079185443 hasBestOaLocation W20791854431 @default.
• W2079185443 hasConcept C101762097 @default.
• W2079185443 hasConcept C104317684 @default.
• W2079185443 hasConcept C127561419 @default.
• W2079185443 hasConcept C134320426 @default.
• W2079185443 hasConcept C138885662 @default.
• W2079185443 hasConcept C150194340 @default.
• W2079185443 hasConcept C153911025 @default.
• W2079185443 hasConcept C159654299 @default.
• W2079185443 hasConcept C165864922 @default.
• W2079185443 hasConcept C173396325 @default.
• W2079185443 hasConcept C179926584 @default.
• W2079185443 hasConcept C180754005 @default.
• W2079185443 hasConcept C183978625 @default.
• W2079185443 hasConcept C27153228 @default.
• W2079185443 hasConcept C2775915377 @default.
• W2079185443 hasConcept C41895202 @default.
• W2079185443 hasConcept C54355233 @default.
• W2079185443 hasConcept C62944979 @default.
• W2079185443 hasConcept C83640560 @default.
• W2079185443 hasConcept C86339819 @default.
• W2079185443 hasConcept C86803240 @default.
• W2079185443 hasConceptScore W2079185443C101762097 @default.
• W2079185443 hasConceptScore W2079185443C104317684 @default.
• W2079185443 hasConceptScore W2079185443C127561419 @default.
• W2079185443 hasConceptScore W2079185443C134320426 @default.
• W2079185443 hasConceptScore W2079185443C138885662 @default.
• W2079185443 hasConceptScore W2079185443C150194340 @default.
• W2079185443 hasConceptScore W2079185443C153911025 @default.
• W2079185443 hasConceptScore W2079185443C159654299 @default.
• W2079185443 hasConceptScore W2079185443C165864922 @default.
• W2079185443 hasConceptScore W2079185443C173396325 @default.
• W2079185443 hasConceptScore W2079185443C179926584 @default.

• next