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• W2079187792 startingPage "2836" @default.
• W2079187792 abstract "Chloropestolide A (1), a highly functionalized spiroketal with an unprecedented skeleton derived from a chlorinated bicyclo-[2.2.2]-oct-2-en-5-one ring and a 2,6-dihydroxy-4-methylbenzoic acid unit, has been isolated from the scale-up fermentation extract of Pestalotiopsis fici. The structure of 1 was elucidated by NMR spectroscopy and X-ray crystallography. 1 could be derived from the same Diels-Alder precursors as 2 and showed significant inhibitory effects on growth of two human cancer cell lines, HeLa and HT29, with GI(50) values of 0.7 and 4.2 microM, respectively." @default.
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• W2079187792 date "2009-06-04" @default.
• W2079187792 modified "2023-09-27" @default.
• W2079187792 title "Chloropestolide A, an Antitumor Metabolite with an Unprecedented Spiroketal Skeleton from <i>Pestalotiopsis fici</i>" @default.
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• W2079187792 doi "https://doi.org/10.1021/ol901039m" @default.
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