Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079187872> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2079187872 endingPage "9011" @default.
- W2079187872 startingPage "9007" @default.
- W2079187872 abstract "To efficiently introduce bovine papillomavirus type 1 genes into cultured cells, we constructed a hybrid viral genome in which the simian virus 40 early region is replaced with a segment of the bovine papillomavirus type 1 transforming region. High-titer stocks of simian virus 40 virions containing the recombinant genome were produced in monkey cells that express simian virus 40 large tumor antigen. Cells infected with this virus efficiently expressed the bovine papillomavirus type 1 E2 and E5 genes. Expression of the E2 gene caused transactivation of genes linked to the bovine papillomavirus type 1 control region, resulting in up to a 1000-fold induction. At high multiplicity of infection of a cell line containing an integrated reporter gene, most cells were infected and responded to transactivation. Within 48 hr of infection with wild-type virus but not with an open reading frame E5 mutant, mouse C127 cells displayed dramatic changes in morphology and growth characteristics similar to those seen in tumorigenic transformation. This system can be used to determine the acute cellular response to introduction of bovine papillomavirus type 1 transforming and regulatory genes; it can also be used to induce foreign genes stably incorporated into cultured mammalian cells." @default.
- W2079187872 created "2016-06-24" @default.
- W2079187872 creator A5028430067 @default.
- W2079187872 creator A5063594666 @default.
- W2079187872 date "1988-12-01" @default.
- W2079187872 modified "2023-09-27" @default.
- W2079187872 title "Efficient transactivation and morphologic transformation by bovine papillomavirus genes expressed from a bovine papillomavirus/simian virus 40 recombinant virus." @default.
- W2079187872 cites W142928915 @default.
- W2079187872 cites W1531193576 @default.
- W2079187872 cites W1532305014 @default.
- W2079187872 cites W1720415932 @default.
- W2079187872 cites W1740513083 @default.
- W2079187872 cites W1773673462 @default.
- W2079187872 cites W1927693030 @default.
- W2079187872 cites W1953046792 @default.
- W2079187872 cites W1966124176 @default.
- W2079187872 cites W1974611875 @default.
- W2079187872 cites W1981168001 @default.
- W2079187872 cites W1981306890 @default.
- W2079187872 cites W1992235627 @default.
- W2079187872 cites W1996672697 @default.
- W2079187872 cites W2019587052 @default.
- W2079187872 cites W2033533503 @default.
- W2079187872 cites W2035655668 @default.
- W2079187872 cites W2057944550 @default.
- W2079187872 cites W2081881255 @default.
- W2079187872 cites W2097724340 @default.
- W2079187872 cites W2117477363 @default.
- W2079187872 cites W2144206181 @default.
- W2079187872 cites W2170499910 @default.
- W2079187872 cites W2418905014 @default.
- W2079187872 cites W57919567 @default.
- W2079187872 cites W2030850838 @default.
- W2079187872 doi "https://doi.org/10.1073/pnas.85.23.9007" @default.
- W2079187872 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/282651" @default.
- W2079187872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2848252" @default.
- W2079187872 hasPublicationYear "1988" @default.
- W2079187872 type Work @default.
- W2079187872 sameAs 2079187872 @default.
- W2079187872 citedByCount "41" @default.
- W2079187872 countsByYear W20791878722012 @default.
- W2079187872 countsByYear W20791878722016 @default.
- W2079187872 crossrefType "journal-article" @default.
- W2079187872 hasAuthorship W2079187872A5028430067 @default.
- W2079187872 hasAuthorship W2079187872A5063594666 @default.
- W2079187872 hasBestOaLocation W20791878722 @default.
- W2079187872 hasConcept C104317684 @default.
- W2079187872 hasConcept C1292079 @default.
- W2079187872 hasConcept C141231307 @default.
- W2079187872 hasConcept C150194340 @default.
- W2079187872 hasConcept C153911025 @default.
- W2079187872 hasConcept C159047783 @default.
- W2079187872 hasConcept C2522874641 @default.
- W2079187872 hasConcept C2776781592 @default.
- W2079187872 hasConcept C39060996 @default.
- W2079187872 hasConcept C40767141 @default.
- W2079187872 hasConcept C54355233 @default.
- W2079187872 hasConcept C86803240 @default.
- W2079187872 hasConceptScore W2079187872C104317684 @default.
- W2079187872 hasConceptScore W2079187872C1292079 @default.
- W2079187872 hasConceptScore W2079187872C141231307 @default.
- W2079187872 hasConceptScore W2079187872C150194340 @default.
- W2079187872 hasConceptScore W2079187872C153911025 @default.
- W2079187872 hasConceptScore W2079187872C159047783 @default.
- W2079187872 hasConceptScore W2079187872C2522874641 @default.
- W2079187872 hasConceptScore W2079187872C2776781592 @default.
- W2079187872 hasConceptScore W2079187872C39060996 @default.
- W2079187872 hasConceptScore W2079187872C40767141 @default.
- W2079187872 hasConceptScore W2079187872C54355233 @default.
- W2079187872 hasConceptScore W2079187872C86803240 @default.
- W2079187872 hasIssue "23" @default.
- W2079187872 hasLocation W20791878721 @default.
- W2079187872 hasLocation W20791878722 @default.
- W2079187872 hasLocation W20791878723 @default.
- W2079187872 hasLocation W20791878724 @default.
- W2079187872 hasOpenAccess W2079187872 @default.
- W2079187872 hasPrimaryLocation W20791878721 @default.
- W2079187872 hasRelatedWork W1024660077 @default.
- W2079187872 hasRelatedWork W1965597722 @default.
- W2079187872 hasRelatedWork W1970057644 @default.
- W2079187872 hasRelatedWork W2014851436 @default.
- W2079187872 hasRelatedWork W2023089872 @default.
- W2079187872 hasRelatedWork W2075636494 @default.
- W2079187872 hasRelatedWork W2075870928 @default.
- W2079187872 hasRelatedWork W2088538321 @default.
- W2079187872 hasRelatedWork W2362994181 @default.
- W2079187872 hasRelatedWork W2407030612 @default.
- W2079187872 hasVolume "85" @default.
- W2079187872 isParatext "false" @default.
- W2079187872 isRetracted "false" @default.
- W2079187872 magId "2079187872" @default.
- W2079187872 workType "article" @default.