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- W2079188619 abstract "Upregulation of heme oxygenase (HO)-1, a heat shock protein 32, protects against hepatic ischemia/reperfusion (I/R) injury. Activation of innate toll-like receptor (TLR) 4 system triggers the I/R injury cascade. This study explores cytoprotective functions of HO-1 overexpression following exogenous administration of cobalt protoporphyrin (CoPP), and its relationship with the TLR4 pathway in a model of mouse partial hepatic warm I/R injury. CoPP treatment markedly improved hepatic function and histology, and suppressed pro-inflammatory cytokine elaboration profile, as compared with untreated controls. Although administration of CoPP did not affect intrahepatic TLR4, it downregulated IFN-inducible protein 10 (IP-10) expression. As IP-10 is the major product of type-1 IFN pathway downstream of TLR4, we then infused recombinant IFN-beta (rIFN-beta) directly into mouse livers. Interestingly, infusion of rIFN-beta upregulated hepatic IP-10 expression. In contrast, adjunctive CoPP treatment decreased IP-10 levels in mouse livers infused with rIFN-beta. Thus, CoPP-induced HO-1 upregulation suppresses type-1 IFN pathway downstream of TLR4 system in hepatic warm I/R injury model." @default.
- W2079188619 created "2016-06-24" @default.
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- W2079188619 date "2005-05-01" @default.
- W2079188619 modified "2023-10-18" @default.
- W2079188619 title "HO-1 Upregulation Suppresses Type 1 IFN Pathway in Hepatic Ischemia/Reperfusion Injury" @default.
- W2079188619 cites W2018229946 @default.
- W2079188619 doi "https://doi.org/10.1016/j.transproceed.2005.03.080" @default.
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