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• W2079188851 abstract "The discovery and potency optimization of a series of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1 is described. Micromolar hits taken from high-throughput screening were optimized for biochemical and cellular mechanistic potency to ~10nM, as exemplified by compound 12az. Application of structure-based drug design aided by co-crystal structures of TAK1 with inhibitors significantly shortened the number of iterations required for the optimization." @default.
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• W2079188851 date "2013-08-01" @default.
• W2079188851 modified "2023-10-16" @default.
• W2079188851 title "Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1" @default.
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• W2079188851 doi "https://doi.org/10.1016/j.bmcl.2013.06.053" @default.
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