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- W2079189610 abstract "Cyclosporin A(CsA) has been widely used as an immunosuppressive drug to prevent graft rejection after organ transplantation and to treat several autoimmune disorders such as rhumat arthritis atropic dermatitis, psoriasis an Behcet's disease. Unfortunately, clinical use of CsA is often associated with side effects including hepatoxicity, nephrotoxicity, neurotoxicity, hypertension and gingival overgrowth. The occurrence of CsA-induced gingival overgrowth(CsAGO) is highly variable, but regularly appears in more than 70% of adult transplant recipient. CsAGO may interfere with normal physiologic function such as mastication and speech and may also have a oral hygiene problem and a psychological impact.1) Despite extensive studies over the decades, pathogenesis of CsAGO remains still unsettled. There has been much controversy in pathogenesis of CsAGO with conflicting evidences as to whether it represents a true hyperplasia. Some previous studies have demonstrated that CsA and its major metabolites OL-17 react with a distinct subpopulation of gingival fibroblast, causing an increments in protein synthesis and rate of cell proliferation. Furthermore, these effects of CsA on human fibroblast proliferation may vary according to individual cell strains. In contrast, other previous studies have suggested that CsA increases production of extracellular matrix, collagen and interleukin-6 but simultaneously decreases proliferation of human gingival fibroblast. Nevertheless, it is apparent that CsA increases cell proliferation of human gingival fibroblast in vitro." @default.
- W2079189610 created "2016-06-24" @default.
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- W2079189610 date "2005-01-01" @default.
- W2079189610 modified "2023-10-17" @default.
- W2079189610 title "Involvement of apoptotic signals in cyclosporin A-induced proliferation of human gingival fibroblast" @default.
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- W2079189610 doi "https://doi.org/10.5051/jkape.2005.35.3.731" @default.
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