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• W2079189684 abstract "Editorials15 March 1994Cryptosporidium parvum: Household TransmissionWilliam L. Current, PhDWilliam L. Current, PhDLilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285-0428.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-120-6-199403150-00012 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Diarrheal disease, particularly in children residing in developing countries, is still a major cause of illness and death. Estimates for the late 1970s and early 1980s [1] suggested that in Asia, Africa, and Latin America alone more than 5 billion episodes of diarrheal illness and 5 to 10 million diarrhea-associated deaths occurred annually. More recent estimates [2] from the World Health Organization provide additional perspective on the worldwide problem of diarrheal illness in children. The World Health Organization estimated that in 1991, 4.3 million deaths occurred in children from acute respiratory infections, 3.5 million from diarrheal diseases, approximately 1 million ...References1. Walsh JA, Warren KS. Selective primary care: an interim strategy for disease control in developing countries. N Engl J Med. 1979; 301:967-74. Google Scholar2. World Health Organization. Division of Epidemiological Surveillance and Health Situation and Trend Assessment. Global estimates for health situation assessment and projections, 1990. Geneva: World Health Organization; 1990. Google Scholar3. Current WL, Garcia LS. Cryptosporidiosis. Clin Microbiol Rev. 1991; 4:325-58. Google Scholar4. Newman RD, Zu SX, Wuhib T, Lima AA, Guerrant RL, Sears SL. Household epidemiology of Cryptosporidium parvum infection in an urban community in northeast Brazil. Ann Intern Med. 1994; 120: 500-5. Google Scholar5. Clarke JJ. A study of coccidia met with in mice. J Micros Soc. 1895; 37:277-302. Google Scholar6. Tyzzer EE. An extracellular coccidium, Cryptosporidium muris (gen et sp nov.) of the gastric glands of the common mouse. J Med Res. 1910; 23:487-516. Google Scholar7. Tyzzer EE. Cryptosporidium parvum (sp. nov.) a coccidium found in the small intestine of the common mouse. Arch Protistenkd. 1912; 26:394-412. Google Scholar8. Meisel JL, Perera DR, Meligro C, Rubin CE. Overwhelming watery diarrhea associated with a Cryptosporidium in an immunosuppressed patient. Gastroenterology. 1976; 70:1156-60. Google Scholar9. Nime FA, Burek JD, Page DL, Holscher MA, Yardley JH. Acute enterocolitis in a human being infected with the protozoan Cryptosporidium. Gastroenterology. 1976; 70:592-8. Google Scholar10. Current WL, Reese NC, Ernst JV, Bailey WS, Heyman MB, Weinstein MD. Human cryptosporidiosis in immunocompetent and immunodeficient persons. Studies of an outbreak and experimental transmission. N Engl J Med. 1983; 308:1252-7. Google Scholar11. Ungar BL. Cryptosporidiosis in humans (Homo sapiens). In: Dubey JP, Speer CA, Fayer R, eds. Cryptosporidiosis of Man and Animals. Boca Raton: CRC Press; 1990:59-82. Google Scholar12. Current WL, Bick PH. Immunobiology of Cryptosporidium spp. Pathol Immunopathol Res. 1989; 8:141-60. Google Scholar13. Reese NC, Current WL, Ernst JV, Bailey WS. Cryptosporidiosis of man and calf: a case report and results of experimental infections in mice and rats. Am J Trop Med Hyg. 1982; 31:226-9. Google Scholar14. Driscoll MS, Thomas VL, Sanford BA. Cryptosporidium infection in day-care centers (Letter). Drug Intell Clin Pharm. 1988; 22:636. Google Scholar15. Cryptosporidiosis among children attending day-care centers—Georgia, Pennsylvania, Michigan, California, New Mexico. MMWR Morbid Mortal Wkly Rep. 1984; 33:599-601. Google Scholar16. Gallaher MM, Herndon JL, Nims LJ, Sterling CR, Grabowski DJ, Hull HF. Cryptosporidiosis and surface water. Am J Public Health. 1989; 79:39-42. Google Scholar17. Hayes EB, Matte TD, O'Brien TR, McKinley TW, Logsdon GS, Rose JB, et al. Large community outbreak of cryptosporidiosis due to contamination of a filtered public water supply. N Engl J Med. 1989; 320:1372-6. Google Scholar18. Sterling CR, Seegar K, Sinclair NA. Cryptosporidium as a causative agent of traveler's diarrhea (Letter). J Infect Dis. 1986; 153:380-1. Google Scholar Author, Article, and Disclosure InformationAffiliations: Lilly Research Laboratories, Eli Lilly & Co., Indianapolis, IN 46285-0428.Corresponding Author: William L. Current, PhD, Mail Drop 0428, Lilly Corporate Center, Indianapolis, IN 46285-0428. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoHousehold Epidemiology of Cryptosporidium parvum Infection in an Urban Community in Northeast Brazil Robert D. Newman , Shu-Xian Zu , Tadesse Wuhib , Aldo A. M. Lima , Richard L. Guerrant , and Cynthia L. Sears Metrics Cited ByGenetic diversity of Cryptosporidium species in Njoro Sub County, Nakuru, KenyaParasites After Hematopoietic Stem Cell or Solid Organ TransplantationRetrospective Study of Cryptosporidiosis Among Diarrhoeic Children in the Arid Region of North-Eastern NigeriaEmerging Enteric Protozoa: Cryptosporidium , Cyciospora , and MicrosporidiaChildhood Cryptosporidium infection among aboriginal communities in Peninsular MalaysiaInfectious Diarrhea from Wilderness and Foreign TravelInferring Infection Transmission Parameters That Influence Water Treatment DecisionsIsolation and Identification of the Waterborne Protozoan Parasites Cryptosporidium spp. and Giardia spp., and Their Presence on Restricted and Unrestricted Irrigated Vegetables in IsraelGASTROINTESTINAL INFECTIONS IN THE IMMUNOCOMPROMISED HOSTHuman intestinal infection due to coccidia in Mozambique: two casesSimple and rapid measurement of Cryptosporidium excystation using flow cytometryWater‐borne cryptosporidiosis: a recurring problemThe Cryptosporidium Problem in Water and Food SuppliesWaterborne protozoan pathogensCryptosporidium and cryptosporidiosisHuman cryptosporidiosis‘The Tropics in Our Bathroom’: Chronic Diarrhoea after Return from the TropicsMicrobial Risk Assessment for Drinking Water 15 March 1994Volume 120, Issue 6Page: 518-519KeywordsAIDSChildrenCryptosporidiosisCryptosporidiumDiarrheaGastrointestinal infectionsGlobal healthImmunityOocystsPediatric infections Issue Published: 15 March 1994 CopyrightCopyright © 1994 by American College of Physicians. 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