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- W2079195016 endingPage "162" @default.
- W2079195016 startingPage "152" @default.
- W2079195016 abstract "Abstract In 2006, Shinya Yamanaka and colleagues discovered how to reprogram terminally differentiated somatic cells to a pluripotent stem cell state. The resulting induced pluripotent stem cells (iPSCs) made a paradigm shift in the field, further nailing down the disproval of the long‐held dogma that differentiation is unidirectional. The prospect of using iPSCs for patient‐specific cell‐based therapies has been enticing. This promise, however, has been questioned in the last two years as several studies demonstrated intrinsic epigenetic and genomic anomalies in these cells. Here, we not only review the recent critical studies addressing the genome integrity during the reprogramming process, but speculate about the underlying mechanisms that could create de novo genome damage in iPSCs. Finally, we discuss how much an elevated mutation load really matters considering the safety of future therapies with cells heavily cultured in vitro." @default.
- W2079195016 created "2016-06-24" @default.
- W2079195016 creator A5004664011 @default.
- W2079195016 creator A5011105258 @default.
- W2079195016 creator A5088790968 @default.
- W2079195016 date "2012-11-22" @default.
- W2079195016 modified "2023-10-16" @default.
- W2079195016 title "Genome damage in induced pluripotent stem cells: Assessing the mechanisms and their consequences" @default.
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- W2079195016 doi "https://doi.org/10.1002/bies.201200114" @default.
- W2079195016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23172728" @default.