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- W2079196802 abstract "BACKGROUND & AIMSHepatitis C virus (HCV) has a high propensity to establish persistence; better understanding of this process requires the development of a fully permissive and immunocompetent small animal model. Mouse cells can be engineered to express the human orthologs of the entry molecules CD81 and occludin to allow entry of HCV. However, RNA replication is poor in mouse cells, and it is not clear whether they support assembly and release of infectious HCV particles. We used a trans-complementation-based system to demonstrate HCV assembly competence of mouse liver cell lines." @default.
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- W2079196802 date "2012-01-27" @default.
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- W2079196802 title "Exiting from uncharted territory: Hepatitis C virus assembles in mouse cell lines" @default.
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- W2079196802 doi "https://doi.org/10.1002/hep.24716" @default.
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