Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079200535> ?p ?o ?g. }
- W2079200535 endingPage "1167" @default.
- W2079200535 startingPage "1151" @default.
- W2079200535 abstract "T cells in vivo have been shown to accumulate DNA damage with age. To investigate the effects of DNA damage on T cell biology we have utilised an in vitro human CD4+ T cell clone model. Levels and types of DNA damage were determined in 11 independent T cell clones as a function of their in vitro lifespan. Increased levels of reactive oxygen species (ROS) induced DNA damage with increasing age were found in all clones analysed using a modified alkaline comet assay. T cell clones underwent apoptosis at the end of their lifespans. There were no consistent changes in the mRNA levels for the cyclin-dependent kinase inhibitors (CKI) p16, p21, and p27 during the clones' lifespans. It appears that the increased levels of ROS induced DNA damage in the T cells is not the major trigger of apoptosis, via the p53/p21 pathway. In addition, at the end of their lifespans, the T cell clones did not display the CKI phenotype reported for senescent cells (an increase in p16 and p21 levels). Thus, while the T cell clones appear sensitive to ROS-induced DNA damage, the molecular mechanisms through which this influences T cell dysfunction with age remains to be elucidated." @default.
- W2079200535 created "2016-06-24" @default.
- W2079200535 creator A5027331206 @default.
- W2079200535 creator A5047564185 @default.
- W2079200535 creator A5066898814 @default.
- W2079200535 creator A5069871797 @default.
- W2079200535 date "2001-08-01" @default.
- W2079200535 modified "2023-09-25" @default.
- W2079200535 title "Age-related accumulation of oxidative DNA damage and alterations in levels of p16INK4a/CDKN2a, p21WAF1/CIP1/SDI1 and p27KIP1 in human CD4+ T cell clones in vitro" @default.
- W2079200535 cites W1493657798 @default.
- W2079200535 cites W1550294225 @default.
- W2079200535 cites W1942724768 @default.
- W2079200535 cites W1968499584 @default.
- W2079200535 cites W1969190950 @default.
- W2079200535 cites W1970867969 @default.
- W2079200535 cites W1971691453 @default.
- W2079200535 cites W1973573758 @default.
- W2079200535 cites W1975324295 @default.
- W2079200535 cites W1977753360 @default.
- W2079200535 cites W1980720313 @default.
- W2079200535 cites W1981383667 @default.
- W2079200535 cites W1982538054 @default.
- W2079200535 cites W1982768428 @default.
- W2079200535 cites W1983991488 @default.
- W2079200535 cites W1986763150 @default.
- W2079200535 cites W1988707875 @default.
- W2079200535 cites W1990743609 @default.
- W2079200535 cites W1993142368 @default.
- W2079200535 cites W1995239001 @default.
- W2079200535 cites W1995920508 @default.
- W2079200535 cites W2004314923 @default.
- W2079200535 cites W2007772649 @default.
- W2079200535 cites W2007854325 @default.
- W2079200535 cites W2011482325 @default.
- W2079200535 cites W2013754365 @default.
- W2079200535 cites W2015250099 @default.
- W2079200535 cites W2015519364 @default.
- W2079200535 cites W2016273822 @default.
- W2079200535 cites W2022511995 @default.
- W2079200535 cites W2024876727 @default.
- W2079200535 cites W2029862426 @default.
- W2079200535 cites W2030414136 @default.
- W2079200535 cites W2033015473 @default.
- W2079200535 cites W2034129646 @default.
- W2079200535 cites W2037915406 @default.
- W2079200535 cites W2045928865 @default.
- W2079200535 cites W2048335195 @default.
- W2079200535 cites W2050551830 @default.
- W2079200535 cites W2051721188 @default.
- W2079200535 cites W2055085859 @default.
- W2079200535 cites W2057257609 @default.
- W2079200535 cites W2059981698 @default.
- W2079200535 cites W2062343447 @default.
- W2079200535 cites W2070061120 @default.
- W2079200535 cites W2073851375 @default.
- W2079200535 cites W2084237578 @default.
- W2079200535 cites W2089500922 @default.
- W2079200535 cites W2092629964 @default.
- W2079200535 cites W2111450457 @default.
- W2079200535 cites W2132969285 @default.
- W2079200535 cites W2135981246 @default.
- W2079200535 cites W2147242002 @default.
- W2079200535 cites W2148837825 @default.
- W2079200535 cites W2157033538 @default.
- W2079200535 cites W2163470365 @default.
- W2079200535 cites W2320706326 @default.
- W2079200535 cites W2966127527 @default.
- W2079200535 doi "https://doi.org/10.1016/s0047-6374(01)00254-8" @default.
- W2079200535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11389930" @default.
- W2079200535 hasPublicationYear "2001" @default.
- W2079200535 type Work @default.
- W2079200535 sameAs 2079200535 @default.
- W2079200535 citedByCount "42" @default.
- W2079200535 countsByYear W20792005352013 @default.
- W2079200535 countsByYear W20792005352014 @default.
- W2079200535 countsByYear W20792005352015 @default.
- W2079200535 countsByYear W20792005352016 @default.
- W2079200535 countsByYear W20792005352017 @default.
- W2079200535 countsByYear W20792005352018 @default.
- W2079200535 countsByYear W20792005352019 @default.
- W2079200535 countsByYear W20792005352020 @default.
- W2079200535 crossrefType "journal-article" @default.
- W2079200535 hasAuthorship W2079200535A5027331206 @default.
- W2079200535 hasAuthorship W2079200535A5047564185 @default.
- W2079200535 hasAuthorship W2079200535A5066898814 @default.
- W2079200535 hasAuthorship W2079200535A5069871797 @default.
- W2079200535 hasConcept C104317684 @default.
- W2079200535 hasConcept C143425029 @default.
- W2079200535 hasConcept C1491633281 @default.
- W2079200535 hasConcept C153911025 @default.
- W2079200535 hasConcept C190283241 @default.
- W2079200535 hasConcept C202751555 @default.
- W2079200535 hasConcept C2780265364 @default.
- W2079200535 hasConcept C2780358455 @default.
- W2079200535 hasConcept C31573885 @default.
- W2079200535 hasConcept C48349386 @default.
- W2079200535 hasConcept C54355233 @default.
- W2079200535 hasConcept C552990157 @default.