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- W2079202357 abstract "We report a novel putative serine/threonine protein kinase containing a leucine-zipper domain, isolated from an human neuronal cell line. The teratocarcinoma cell line NT2 was differentiated to postmitotic NT2-N neurons by treatment with retinoic acid, and degenerate oligonucleotide primers to the catalytic domains of protein kinases were employed to PCR amplify subtractive cDNAs. We identified a clone, represented at higher abundance in NT2-N neurons than in the parental cell line, which encodes a putative serine/threonine kinase of 668 aminoacids, the leucine-zipper protein kinase (zpk). Zpk protein contains a leucine-zipper domain, found in many DNA-binding proteins, but few protein kinases. Steady-state mRNA levels for zpk are high in human brain and kidney. Further studies are required to evaluate the role of zpk in neuronal differentiation." @default.
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- W2079202357 date "1994-07-01" @default.
- W2079202357 modified "2023-09-25" @default.
- W2079202357 title "Cloning of a Novel Putative Protein Kinase Having a Leucine Zipper Domain from Human Brain" @default.
- W2079202357 doi "https://doi.org/10.1006/bbrc.1994.1972" @default.
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