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• W2079203989 startingPage "1418" @default.
• W2079203989 abstract "Childhood-onset schizophrenia (defined by an onset of psychosis by age 12) is a rare and severe form of the disorder that is clinically and neurobiologically continuous with the adult-onset disorder. There is growing evidence for more salient risk or etiologic factors, particularly familial, in this possibly more homogeneous patient population. For the 49 patients with very early onset schizophrenia studied to date at the National Institute of Mental Health, there were more severe premorbid neuro-developmental abnormalities, a higher rate of cytogenetic anomalies, and a seemingly higher rate of familial schizophrenia and spectrum disorders than later onset cases. There was no evidence for increased obstetric complications or environmental stress. These data, while preliminary, suggest that a very early age of onset of schizophrenia may be secondary to greater familial vulnerability. Consequently, genetic studies of these patients may be particularly informative and may provide important etiologic information." @default.
• W2079203989 created "2016-06-24" @default.
• W2079203989 creator A5013334134 @default.
• W2079203989 creator A5016908990 @default.
• W2079203989 date "1999-11-01" @default.
• W2079203989 modified "2023-10-10" @default.
• W2079203989 title "Childhood-onset schizophrenia: rare but worth studying" @default.
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• W2079203989 doi "https://doi.org/10.1016/s0006-3223(99)00231-0" @default.
• W2079203989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10578456" @default.
• W2079203989 hasPublicationYear "1999" @default.
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