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- W2079204151 abstract "The Wild-type p53-induced phosphatase 1, Wip1 (or PPM1D), is unusual in that it is a serine/threonine phosphatase with oncogenic activity. A member of the type 2C phosphatases (PP2Cδ), Wip1 has been shown to be amplified and overexpressed in multiple human cancer types, including breast and ovarian carcinomas. In rodent primary fibroblast transformation assays, Wip1 cooperates with known oncogenes to induce transformed foci. The recent identification of target proteins that are dephosphorylated by Wip1 has provided mechanistic insights into its oncogenic functions. Wip1 acts as a homeostatic regulator of the DNA damage response by dephosphorylating proteins that are substrates of both ATM and ATR, important DNA damage sensor kinases. Wip1 also suppresses the activity of multiple tumor suppressors, including p53, ATM, p16INK4a and ARF. We present evidence that the suppression of p53, p38 MAP kinase, and ATM/ATR signaling pathways by Wip1 are important components of its oncogenicity when it is amplified and overexpressed in human cancers." @default.
- W2079204151 created "2016-06-24" @default.
- W2079204151 creator A5064534768 @default.
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- W2079204151 date "2008-02-12" @default.
- W2079204151 modified "2023-10-02" @default.
- W2079204151 title "The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways" @default.
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- W2079204151 doi "https://doi.org/10.1007/s10555-008-9127-x" @default.
- W2079204151 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2362138" @default.
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