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• W2079206739 startingPage "1347" @default.
• W2079206739 abstract "MicroRNAs (miRNAs) are small non-coding RNAs of ~22 nucleotides that function as negative regulators of gene expression by either inhibiting translation or inducing deadenylation-dependent degradation of target transcripts. Notably, deregulation of miRNAs expression is associated with the initiation and progression of human cancers where they act as oncogenes or tumor suppressors contributing to tumorigenesis. Abnormal miRNA expression may provide potential diagnostic and prognostic tumor biomarkers and new therapeutic targets in cancer. Recently, several miRNAs have been shown to initiate invasion and metastasis by targeting multiple proteins that are major players in these cellular events, thus they have been denominated as metastamiRs. Here, we present a review of the current knowledge of miRNAs in cancer with a special focus on metastamiRs. In addition we discuss their potential use as novel specific markers for cancer progression." @default.
• W2079206739 created "2016-06-24" @default.
• W2079206739 creator A5001248616 @default.
• W2079206739 creator A5010204285 @default.
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• W2079206739 creator A5031196026 @default.
• W2079206739 creator A5058265795 @default.
• W2079206739 creator A5089861673 @default.
• W2079206739 date "2012-01-27" @default.
• W2079206739 modified "2023-10-18" @default.
• W2079206739 title "MetastamiRs: Non-Coding MicroRNAs Driving Cancer Invasion and Metastasis" @default.
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