Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079206812> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2079206812 endingPage "S9" @default.
- W2079206812 startingPage "S2" @default.
- W2079206812 abstract "The narrow therapeutic window of cyclosporine (CsA) requires close therapeutic drug monitoring (TDM). While C2-TDM has been established after renal and liver transplantations, clinical experience is limited for patients after de novo heart transplantation (HTX).In a retrospective study, we investigated 40 patients undergoing HTX; 34 patients received induction therapy using antithymocyte globulin (ATG Mérieux). Immunosuppression was administered with CsA (Sandimmun-Optoral), with dosages adjusted according to C2 levels (800–1100 ng/mL during the first 6 months and reduced to 400–600 ng/mL from the beginning of the first year). At different times TI (months 1–3). TII (months 12–14) TIII (months 24–26), and TIV (months 34–36), we obtained measures of acute cellular rejections (ARs), cytomegalovirus (CMV) infections, creatinine, and safety laboratory parameters.The cumulative survival was 95% after 1 year, and 88% after 3.8 years. Eight ARs were diagnosed at a mean of 7.6 months after HTX in 7 patients. Twenty-four CMV infections/reactivations were verified. In 10 cases, treatment was started because of clinical symptoms. The mean creatinine values significantly rose in the early postoperative phase (TI: 1.23 ± 0.47 mg/dL, TII: 1.49 ± 0.41 mg/dL; P < .0001). Thereafter the creatinine values declined; however, this was not statistically significant (TIII: 1.38 ± 0.57 mg/dL, TIV: 1.15 ± 0.30 mg/dL). All other safety parameters showed no significant changes.C2 allows individualization of immunosuppression with reduced CsA toxicity, but without loss in safety among de novo patients after HTX. We obtained freedom from severe AR, a low number of CMV infections, and excellent patient survival." @default.
- W2079206812 created "2016-06-24" @default.
- W2079206812 creator A5073401589 @default.
- W2079206812 date "2000-05-01" @default.
- W2079206812 modified "2023-10-14" @default.
- W2079206812 title "Neoral use in the liver transplant recipient" @default.
- W2079206812 cites W1969837093 @default.
- W2079206812 cites W1997796472 @default.
- W2079206812 cites W2004314116 @default.
- W2079206812 cites W2006179524 @default.
- W2079206812 cites W2007066337 @default.
- W2079206812 cites W2019935543 @default.
- W2079206812 cites W2041951312 @default.
- W2079206812 cites W2049170691 @default.
- W2079206812 cites W2057567503 @default.
- W2079206812 cites W2058219920 @default.
- W2079206812 cites W2058567074 @default.
- W2079206812 cites W2073525411 @default.
- W2079206812 cites W2077646228 @default.
- W2079206812 cites W2081031170 @default.
- W2079206812 cites W2081343096 @default.
- W2079206812 cites W2092075764 @default.
- W2079206812 cites W2094241976 @default.
- W2079206812 cites W2094883200 @default.
- W2079206812 cites W2106911513 @default.
- W2079206812 cites W2110872657 @default.
- W2079206812 cites W2158198634 @default.
- W2079206812 cites W2169824181 @default.
- W2079206812 cites W2186344734 @default.
- W2079206812 cites W4230154854 @default.
- W2079206812 cites W4233901727 @default.
- W2079206812 cites W4238637783 @default.
- W2079206812 cites W4255940022 @default.
- W2079206812 doi "https://doi.org/10.1016/s0041-1345(00)00859-9" @default.
- W2079206812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10814745" @default.
- W2079206812 hasPublicationYear "2000" @default.
- W2079206812 type Work @default.
- W2079206812 sameAs 2079206812 @default.
- W2079206812 citedByCount "12" @default.
- W2079206812 countsByYear W20792068122012 @default.
- W2079206812 crossrefType "journal-article" @default.
- W2079206812 hasAuthorship W2079206812A5073401589 @default.
- W2079206812 hasConcept C112705442 @default.
- W2079206812 hasConcept C126322002 @default.
- W2079206812 hasConcept C126894567 @default.
- W2079206812 hasConcept C141071460 @default.
- W2079206812 hasConcept C159641895 @default.
- W2079206812 hasConcept C162156334 @default.
- W2079206812 hasConcept C167135981 @default.
- W2079206812 hasConcept C197934379 @default.
- W2079206812 hasConcept C2776694085 @default.
- W2079206812 hasConcept C2779609443 @default.
- W2079206812 hasConcept C2780252810 @default.
- W2079206812 hasConcept C2780272996 @default.
- W2079206812 hasConcept C2780306776 @default.
- W2079206812 hasConcept C2911091166 @default.
- W2079206812 hasConcept C29730261 @default.
- W2079206812 hasConcept C71924100 @default.
- W2079206812 hasConcept C90924648 @default.
- W2079206812 hasConceptScore W2079206812C112705442 @default.
- W2079206812 hasConceptScore W2079206812C126322002 @default.
- W2079206812 hasConceptScore W2079206812C126894567 @default.
- W2079206812 hasConceptScore W2079206812C141071460 @default.
- W2079206812 hasConceptScore W2079206812C159641895 @default.
- W2079206812 hasConceptScore W2079206812C162156334 @default.
- W2079206812 hasConceptScore W2079206812C167135981 @default.
- W2079206812 hasConceptScore W2079206812C197934379 @default.
- W2079206812 hasConceptScore W2079206812C2776694085 @default.
- W2079206812 hasConceptScore W2079206812C2779609443 @default.
- W2079206812 hasConceptScore W2079206812C2780252810 @default.
- W2079206812 hasConceptScore W2079206812C2780272996 @default.
- W2079206812 hasConceptScore W2079206812C2780306776 @default.
- W2079206812 hasConceptScore W2079206812C2911091166 @default.
- W2079206812 hasConceptScore W2079206812C29730261 @default.
- W2079206812 hasConceptScore W2079206812C71924100 @default.
- W2079206812 hasConceptScore W2079206812C90924648 @default.
- W2079206812 hasIssue "3" @default.
- W2079206812 hasLocation W20792068121 @default.
- W2079206812 hasLocation W20792068122 @default.
- W2079206812 hasOpenAccess W2079206812 @default.
- W2079206812 hasPrimaryLocation W20792068121 @default.
- W2079206812 hasRelatedWork W1486584413 @default.
- W2079206812 hasRelatedWork W1544023406 @default.
- W2079206812 hasRelatedWork W1973741567 @default.
- W2079206812 hasRelatedWork W1974378936 @default.
- W2079206812 hasRelatedWork W2046899919 @default.
- W2079206812 hasRelatedWork W2079206812 @default.
- W2079206812 hasRelatedWork W2087086071 @default.
- W2079206812 hasRelatedWork W2330154650 @default.
- W2079206812 hasRelatedWork W3117263584 @default.
- W2079206812 hasRelatedWork W393698729 @default.
- W2079206812 hasVolume "32" @default.
- W2079206812 isParatext "false" @default.
- W2079206812 isRetracted "false" @default.
- W2079206812 magId "2079206812" @default.
- W2079206812 workType "article" @default.