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• W2079207360 abstract "Introduction: Hemorrhagic shock is a major factor of morbidity and mortality in trauma patients. Adenosine triphosphate (ATP) depletion is believed to be one of the central biochemical abnormalities in shock and supplementation of ATP will be a workable solution. A new direct intracellular ATP delivery system (ATP- vesicles) has been developed to provide ATP to maintain cell viability during hemorrhage and hypoxia. Methods: Male Sprague Dawley rats, weighing 270 to 330 g, were anesthetized with sodium pentobarbital (40 mg/kg, ip). Hemorrhage was performed by withdrawing 27 mL/kg of blood (approximately 40% of total blood volume) during a 10 minute-period through the femoral venous catheter using a Harvard Apparatus infusion and withdrawal pump. The animals were then subjected to a continuous venous bleeding of 8 mL/kg during the 60-minute shock period to imitate the clinic setting: initial brisk bleeding and slow venous oozing during shock. The animals were randomized to three groups that were administrated different treatment solutions intravenously: Lactated Ringer’s (LR, n=8); 5 mM Free Mg-ATP + Ringer’s (FR, n=6); 5 mM ATP-Vesicles + Ringer’s (VR, n=8). The total volumes infused were equal to 2 times the volume of shed blood and the speed of infusion was 0.5 ml/min. The treatments and resuscitation continued up to 4 hours. Results: The change of mean arterial pressure (MAP) is showed in the figure. When total of 40% blood volume was withdrawn, MAP dropped to 40-50 mmHg. During the rest period of shock, MAP slowly increased due to the compensation of cardiovascular system. After resuscitation started, MAP in FR group dropped down to 35±5 mmHg, but in the VR group MAP went down only to 52±10 mmHg. When ATP infusion was stopped, MAP increased immediately in the VR group, and maintained the higher levels than other two groups. At the end of experiment there were significant differences between the VR group and FR group (99±8 mmHg vs. 78±5 mmHg, p<0.01) or LR group (67±11 mmHg, p<0.001). No significance was found between the FR and CR groups. The heart wet to dry weight ratio was higher in the CR group (4.60±0.21) than that in the VR group (4.20±0.11 p<0.01) or in the FR group (4.29±0.11, p<0.05). The heart tissue ATP content in the VR group (1.39±0.32 μmol/g wet tissue) tended to be higher than that in the LR group (0.92±0.23 μmol/g wet tissue), but the differences was not significant. Conclusion: In this hemorrhagic shock model, direct intracellular energy delivery appeared to maintain the cardiac function better than LR and free ATP. The possibility of using direct intracellular ATP delivery for treatment of hemorrhagic shock deserves further study." @default.
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• W2079207360 date "2008-02-01" @default.
• W2079207360 modified "2023-09-26" @default.
• W2079207360 title "QS236. Intracellular Energy Delivery for Hemorrhagic Shock in Rats" @default.
• W2079207360 doi "https://doi.org/10.1016/j.jss.2007.12.483" @default.
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