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- W2079208046 abstract "[3H]Idazoxan is a labelled ligand that is frequently used to study α2-adrenoceptors in the central nervous system. In pig kidney membranes, [3H]idazoxan labelled high-affinity binding sites (Kd = 1.5 nM) that were not α2-adrenoptors and which recognized clonidine with low affinity. This new class of binding sites was recognized by amiloride derivatives; however, it is not likely that these sites are the well-known targets of amiloride in the kidney: the Na+/H+ exchanger and the epithelium Na+ channel. These binding sites may be the normal target of a series of imidazolidines derivatives (guanabenz, guanochlor, guanoxan), which are known for their antihypertensive properties." @default.
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- W2079208046 date "1989-01-01" @default.
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- W2079208046 title "Guanabenz, guanochlor, guanoxan and idazoxan bind with high affinity to non-adrenergic sites in pig kidney membranes" @default.
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- W2079208046 doi "https://doi.org/10.1016/0014-2999(89)90503-7" @default.
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