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- W2079209141 abstract "A live infectious bursal disease virus vaccine increased in virulence when passaged six times in susceptible birds as judged by damage to the bursa of Fabricius. It is suggested that the increase in virulence of this vaccine was due to the selection of a virulent subpopulation which had been present in the vaccine since its original isolation from the field and which had not been eliminated during its attenuation by passage in cell culture. The vaccine was then plaque purified and a virus strain was selected which protected against challenge, did not damage the bursa and appeared not to passage in birds." @default.
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- W2079209141 date "1985-09-01" @default.
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- W2079209141 title "Increased virulence of an infectious bursal disease live virus vaccine after passage in chicks" @default.
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- W2079209141 doi "https://doi.org/10.1016/s0264-410x(85)90161-6" @default.
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