FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079210306> ?p ?o ?g. }

• W2079210306 abstract "CpG island hyper-methylation (CIHM) is one of the major events in the gastric carcinogenesis. IL-17A, -17F and MIF have a crucial role in the gastric inflammation and carcinogenesis. Recently, we showed that the genetic polymorphisms of MIF-794-CATT repeat are associated with CIHM status in the non-neoplastic gastric mucosa. Consequently, the CIHM status in the gastric cancer tissue, in relation to IL-17A (-197G>A), -17F (7488T>C), and MIF (-173G>C and -794 tetranucleotide repeats) polymorphisms was investigated. Gastric cancer tissues were obtained from 102 patients. CIHM of p14, p16, DAP-kinase and CDH1 genes were determined by methylation-specific polymerase chain reaction (MSP). CIHM high was defined as three or all CpG islands methylated. We employed the PCR-SSCP (multiplex PCR for IL-17A and -17F) method to detect the gene polymorphisms. We did not find significant association between CIHM status and IL-17F (7488T>C) and MIF (-173G>C) polymorphisms. However, concerning the IL-17A (-197G>A) polymorphism, we found that IL-17A G carrier (GG+GA) held a significantly higher risk of CIHM of p16 (OR=11.22, 95% CI=1.38-91.17, p=0.024) and CIHM high (OR=3.51, 95% CI=1.15-10.68, p=0.027). An association was also found between the 7-CATT repeat carrier (5/7 + 6/7 + 7/7) of the MIF polymorphism (-794-CATT) and reduced risk of CIHM of CDH1 (OR=0.36, 95% CI=0.14-0.92, p=0.032). No association was found between CHIM status and homozygote genotypes of each repeat (-794-CATT 5/5, 6/6, and 7/7). The present results provided evidence that the genetic polymorphisms of IL-17A, and MIF-794-CATT repeat are associated with CIHM status in the gastric cancer. Genetic polymorphisms of IL-17A, and MIF-794-CATT repeat may be involved in methylation-related carcinogenesis in the stomach." @default.
• W2079210306 created "2016-06-24" @default.
• W2079210306 creator A5005528474 @default.
• W2079210306 creator A5007416965 @default.
• W2079210306 creator A5008823379 @default.
• W2079210306 creator A5011133566 @default.
• W2079210306 creator A5020242504 @default.
• W2079210306 creator A5023712329 @default.
• W2079210306 creator A5028540027 @default.
• W2079210306 creator A5043240541 @default.
• W2079210306 creator A5044147495 @default.
• W2079210306 creator A5045596987 @default.
• W2079210306 creator A5050935984 @default.
• W2079210306 creator A5063942983 @default.
• W2079210306 creator A5069070485 @default.
• W2079210306 creator A5076232389 @default.
• W2079210306 creator A5078371702 @default.
• W2079210306 creator A5079534102 @default.
• W2079210306 creator A5083663974 @default.
• W2079210306 date "2010-01-22" @default.
• W2079210306 modified "2023-10-16" @default.
• W2079210306 title "Association between IL-17A, -17F and MIF polymorphisms predispose to CpG island hyper-methylation in gastric cancer" @default.
• W2079210306 doi "https://doi.org/10.3892/ijmm_00000367" @default.
• W2079210306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20127054" @default.
• W2079210306 hasPublicationYear "2010" @default.
• W2079210306 type Work @default.
• W2079210306 sameAs 2079210306 @default.
• W2079210306 citedByCount "25" @default.
• W2079210306 countsByYear W20792103062012 @default.
• W2079210306 countsByYear W20792103062013 @default.
• W2079210306 countsByYear W20792103062014 @default.
• W2079210306 countsByYear W20792103062015 @default.
• W2079210306 countsByYear W20792103062016 @default.
• W2079210306 countsByYear W20792103062017 @default.
• W2079210306 countsByYear W20792103062018 @default.
• W2079210306 countsByYear W20792103062021 @default.
• W2079210306 countsByYear W20792103062022 @default.
• W2079210306 countsByYear W20792103062023 @default.
• W2079210306 crossrefType "journal-article" @default.
• W2079210306 hasAuthorship W2079210306A5005528474 @default.
• W2079210306 hasAuthorship W2079210306A5007416965 @default.
• W2079210306 hasAuthorship W2079210306A5008823379 @default.
• W2079210306 hasAuthorship W2079210306A5011133566 @default.
• W2079210306 hasAuthorship W2079210306A5020242504 @default.
• W2079210306 hasAuthorship W2079210306A5023712329 @default.
• W2079210306 hasAuthorship W2079210306A5028540027 @default.
• W2079210306 hasAuthorship W2079210306A5043240541 @default.
• W2079210306 hasAuthorship W2079210306A5044147495 @default.
• W2079210306 hasAuthorship W2079210306A5045596987 @default.
• W2079210306 hasAuthorship W2079210306A5050935984 @default.
• W2079210306 hasAuthorship W2079210306A5063942983 @default.
• W2079210306 hasAuthorship W2079210306A5069070485 @default.
• W2079210306 hasAuthorship W2079210306A5076232389 @default.
• W2079210306 hasAuthorship W2079210306A5078371702 @default.
• W2079210306 hasAuthorship W2079210306A5079534102 @default.
• W2079210306 hasAuthorship W2079210306A5083663974 @default.
• W2079210306 hasBestOaLocation W20792103061 @default.
• W2079210306 hasConcept C101762097 @default.
• W2079210306 hasConcept C104177226 @default.
• W2079210306 hasConcept C104317684 @default.
• W2079210306 hasConcept C121608353 @default.
• W2079210306 hasConcept C140173407 @default.
• W2079210306 hasConcept C1491633281 @default.
• W2079210306 hasConcept C149402561 @default.
• W2079210306 hasConcept C150194340 @default.
• W2079210306 hasConcept C153911025 @default.
• W2079210306 hasConcept C190727270 @default.
• W2079210306 hasConcept C2776391639 @default.
• W2079210306 hasConcept C2778690821 @default.
• W2079210306 hasConcept C2781018059 @default.
• W2079210306 hasConcept C29537977 @default.
• W2079210306 hasConcept C33288867 @default.
• W2079210306 hasConcept C49105822 @default.
• W2079210306 hasConcept C502942594 @default.
• W2079210306 hasConcept C54355233 @default.
• W2079210306 hasConcept C555283112 @default.
• W2079210306 hasConcept C67082663 @default.
• W2079210306 hasConcept C86803240 @default.
• W2079210306 hasConceptScore W2079210306C101762097 @default.
• W2079210306 hasConceptScore W2079210306C104177226 @default.
• W2079210306 hasConceptScore W2079210306C104317684 @default.
• W2079210306 hasConceptScore W2079210306C121608353 @default.
• W2079210306 hasConceptScore W2079210306C140173407 @default.
• W2079210306 hasConceptScore W2079210306C1491633281 @default.
• W2079210306 hasConceptScore W2079210306C149402561 @default.
• W2079210306 hasConceptScore W2079210306C150194340 @default.
• W2079210306 hasConceptScore W2079210306C153911025 @default.
• W2079210306 hasConceptScore W2079210306C190727270 @default.
• W2079210306 hasConceptScore W2079210306C2776391639 @default.
• W2079210306 hasConceptScore W2079210306C2778690821 @default.
• W2079210306 hasConceptScore W2079210306C2781018059 @default.
• W2079210306 hasConceptScore W2079210306C29537977 @default.
• W2079210306 hasConceptScore W2079210306C33288867 @default.
• W2079210306 hasConceptScore W2079210306C49105822 @default.
• W2079210306 hasConceptScore W2079210306C502942594 @default.
• W2079210306 hasConceptScore W2079210306C54355233 @default.
• W2079210306 hasConceptScore W2079210306C555283112 @default.
• W2079210306 hasConceptScore W2079210306C67082663 @default.
• W2079210306 hasConceptScore W2079210306C86803240 @default.
• W2079210306 hasIssue "3" @default.

• next