FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079211058> ?p ?o ?g. }

• W2079211058 endingPage "164" @default.
• W2079211058 startingPage "159" @default.
• W2079211058 abstract "SCH 37224, 1-(1,2-dihydro-4-hydroxy-2-oxo-1-phenyl-1,8-naphthyridin-3-yl) pyrrolidinium, is a structurally novel compound that had been shown to inhibit leukotriene D4 formation in guinea pig lung in vitro. We tested whether SCH 37224 is able to inhibit both the formation of eicosanoids from human lung parenchyma in vitro and the binding of sulfidopeptide leukotrienes to membranes of lung parenchyma and bronchi. SCH 37224, at a concentration of 30 and 100 μM, was able to inhibit antigen-induced formation of sulfidopeptide leukotrienes, measured as leukotriene E4, while it did not significantly affect the formation of prostaglandin D2. At concentrations up to 100 μM, it did not affect either the binding of [3H]leukotriene C4 to membranes of human lung parenchyma or human bronchi, or the binding of [3H]leukotriene D4 to the parenchyma. In conclusion, SCH 37224 is a selective inhibitor of leukotriene formation in human lung in vitro, which might be of potential therapeutic interest in the treatment of asthma." @default.
• W2079211058 created "2016-06-24" @default.
• W2079211058 creator A5001586303 @default.
• W2079211058 creator A5004327688 @default.
• W2079211058 creator A5023078856 @default.
• W2079211058 creator A5041436204 @default.
• W2079211058 creator A5046610533 @default.
• W2079211058 creator A5058112814 @default.
• W2079211058 creator A5066757751 @default.
• W2079211058 creator A5086913891 @default.
• W2079211058 date "1992-08-01" @default.
• W2079211058 modified "2023-10-18" @default.
• W2079211058 title "Effect of SCH 37224 on anti-IgE-induced formation of sulfidopeptide leukotrienes in human lung parenchyma" @default.
• W2079211058 cites W107907750 @default.
• W2079211058 cites W1509351410 @default.
• W2079211058 cites W1520264805 @default.
• W2079211058 cites W1969841010 @default.
• W2079211058 cites W1973578823 @default.
• W2079211058 cites W1975116298 @default.
• W2079211058 cites W2003503281 @default.
• W2079211058 cites W2004351423 @default.
• W2079211058 cites W2011508883 @default.
• W2079211058 cites W2012524533 @default.
• W2079211058 cites W2030736050 @default.
• W2079211058 cites W2032353595 @default.
• W2079211058 cites W2049796670 @default.
• W2079211058 cites W2052439448 @default.
• W2079211058 cites W2053985622 @default.
• W2079211058 cites W2057241960 @default.
• W2079211058 cites W2119979570 @default.
• W2079211058 cites W2313196016 @default.
• W2079211058 cites W3023211482 @default.
• W2079211058 doi "https://doi.org/10.1016/0014-2999(92)90595-u" @default.
• W2079211058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1397043" @default.
• W2079211058 hasPublicationYear "1992" @default.
• W2079211058 type Work @default.
• W2079211058 sameAs 2079211058 @default.
• W2079211058 citedByCount "1" @default.
• W2079211058 crossrefType "journal-article" @default.
• W2079211058 hasAuthorship W2079211058A5001586303 @default.
• W2079211058 hasAuthorship W2079211058A5004327688 @default.
• W2079211058 hasAuthorship W2079211058A5023078856 @default.
• W2079211058 hasAuthorship W2079211058A5041436204 @default.
• W2079211058 hasAuthorship W2079211058A5046610533 @default.
• W2079211058 hasAuthorship W2079211058A5058112814 @default.
• W2079211058 hasAuthorship W2079211058A5066757751 @default.
• W2079211058 hasAuthorship W2079211058A5086913891 @default.
• W2079211058 hasConcept C126322002 @default.
• W2079211058 hasConcept C134018914 @default.
• W2079211058 hasConcept C142724271 @default.
• W2079211058 hasConcept C185592680 @default.
• W2079211058 hasConcept C196822366 @default.
• W2079211058 hasConcept C202751555 @default.
• W2079211058 hasConcept C203014093 @default.
• W2079211058 hasConcept C2776042228 @default.
• W2079211058 hasConcept C2776452501 @default.
• W2079211058 hasConcept C2776685179 @default.
• W2079211058 hasConcept C2776914184 @default.
• W2079211058 hasConcept C2777242621 @default.
• W2079211058 hasConcept C2777714996 @default.
• W2079211058 hasConcept C2778053663 @default.
• W2079211058 hasConcept C2778815084 @default.
• W2079211058 hasConcept C2779543280 @default.
• W2079211058 hasConcept C2780664492 @default.
• W2079211058 hasConcept C55493867 @default.
• W2079211058 hasConcept C71924100 @default.
• W2079211058 hasConcept C86803240 @default.
• W2079211058 hasConceptScore W2079211058C126322002 @default.
• W2079211058 hasConceptScore W2079211058C134018914 @default.
• W2079211058 hasConceptScore W2079211058C142724271 @default.
• W2079211058 hasConceptScore W2079211058C185592680 @default.
• W2079211058 hasConceptScore W2079211058C196822366 @default.
• W2079211058 hasConceptScore W2079211058C202751555 @default.
• W2079211058 hasConceptScore W2079211058C203014093 @default.
• W2079211058 hasConceptScore W2079211058C2776042228 @default.
• W2079211058 hasConceptScore W2079211058C2776452501 @default.
• W2079211058 hasConceptScore W2079211058C2776685179 @default.
• W2079211058 hasConceptScore W2079211058C2776914184 @default.
• W2079211058 hasConceptScore W2079211058C2777242621 @default.
• W2079211058 hasConceptScore W2079211058C2777714996 @default.
• W2079211058 hasConceptScore W2079211058C2778053663 @default.
• W2079211058 hasConceptScore W2079211058C2778815084 @default.
• W2079211058 hasConceptScore W2079211058C2779543280 @default.
• W2079211058 hasConceptScore W2079211058C2780664492 @default.
• W2079211058 hasConceptScore W2079211058C55493867 @default.
• W2079211058 hasConceptScore W2079211058C71924100 @default.
• W2079211058 hasConceptScore W2079211058C86803240 @default.
• W2079211058 hasIssue "1" @default.
• W2079211058 hasLocation W20792110581 @default.
• W2079211058 hasLocation W20792110582 @default.
• W2079211058 hasOpenAccess W2079211058 @default.
• W2079211058 hasPrimaryLocation W20792110581 @default.
• W2079211058 hasRelatedWork W130131012 @default.
• W2079211058 hasRelatedWork W1528245429 @default.
• W2079211058 hasRelatedWork W2017526943 @default.
• W2079211058 hasRelatedWork W2032544534 @default.
• W2079211058 hasRelatedWork W2035677820 @default.
• W2079211058 hasRelatedWork W2079211058 @default.

• next