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• W2079218706 abstract "ObjectiveTo evaluate the effect of hypothalamic/pituitary radiation (HPT RT) dose on the occurrence of first pregnancy.DesignRetrospective cohort study of childhood cancer 5-year survivors (CCS) diagnosed between 1970 and 1986 before 21 years of age at one of 26 North American pediatric cancer treatment centers.SettingSelf-administered questionnaire.Patient(s)A total of 3,619 female CCS who participated in the Childhood Cancer Survivor Study and received no or scatter (≤0.1 Gy) radiation to the ovaries and 2,081 female siblings (Sibs) of the participants.Intervention(s)None.Main Outcome Measure(s)Self-reported pregnancy events.Result(s)As a group, CCS were as likely to report being pregnant as Sibs (hazard ratio 1.07, 95% confidence interval 0.97–1.19). Multivariable models showed a significant decrease in the risk of pregnancy with HPT RT doses ≥22 Gy compared with those CCS receiving no HPT RT.Conclusion(s)These results support the hypothesis that exposures of 22–27 Gy HPT RT may be a contributing factor to infertility among female CCS. To evaluate the effect of hypothalamic/pituitary radiation (HPT RT) dose on the occurrence of first pregnancy. Retrospective cohort study of childhood cancer 5-year survivors (CCS) diagnosed between 1970 and 1986 before 21 years of age at one of 26 North American pediatric cancer treatment centers. Self-administered questionnaire. A total of 3,619 female CCS who participated in the Childhood Cancer Survivor Study and received no or scatter (≤0.1 Gy) radiation to the ovaries and 2,081 female siblings (Sibs) of the participants. None. Self-reported pregnancy events. As a group, CCS were as likely to report being pregnant as Sibs (hazard ratio 1.07, 95% confidence interval 0.97–1.19). Multivariable models showed a significant decrease in the risk of pregnancy with HPT RT doses ≥22 Gy compared with those CCS receiving no HPT RT. These results support the hypothesis that exposures of 22–27 Gy HPT RT may be a contributing factor to infertility among female CCS." @default.
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• W2079218706 date "2011-05-01" @default.
• W2079218706 modified "2023-10-17" @default.
• W2079218706 title "Decreased fertility among female childhood cancer survivors who received 22–27 Gy hypothalamic/pituitary irradiation: a report from the Childhood Cancer Survivor Study" @default.
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• W2079218706 doi "https://doi.org/10.1016/j.fertnstert.2011.02.002" @default.
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