Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079220627> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2079220627 endingPage "583" @default.
- W2079220627 startingPage "578" @default.
- W2079220627 abstract "T his randomized, examiner masked, split mouth study evaluated a new model to test periodontal therapy involving a novel bioerodible copolymer gel containing tetracycline hydrochloride. Responses to the tetracycline gel and untreated control were compared for product tolerance and 3 different measures of effectiveness (drug retention, changes in microbial levels, and clinical status). The test gel was administered by syringe into the periodontal pockets of 18 systemically healthy adult volunteers, each of whom presented with 3 or more sites with 6 mm probing depths. Gingival crevicular fluid samples were used to monitor daily drug levels over 7 days, while clinical responses were assessed at day 30. Overall, the test gel was well‐tolerated by all patients. For the 3 effectiveness measures, tetracycline was released throughout the observation period and mean levels exceeded 100 μg/mL over 6 days, statistically significant reductions in selected periodontal pathogens were evident at day 7 but not at day 30, and mean probing depth reductions at test sites were 1.12 mm at 30 days versus 0.36 mm at untreated control sites ( P = 0.012). The safety profile, longer‐term drug retention, antimicrobial activity, and clinical response in this Phase I study suggest that this tetracycline‐containing copolymer gel platform may represent a safe and effective bioerodible therapy for periodontitis. The experimental model also shows merit for early phase clinical testing of novel therapeutic agents. J Periodontol 1998;69:578–583 ." @default.
- W2079220627 created "2016-06-24" @default.
- W2079220627 creator A5018103318 @default.
- W2079220627 creator A5037840112 @default.
- W2079220627 creator A5063463731 @default.
- W2079220627 creator A5070714240 @default.
- W2079220627 creator A5089520411 @default.
- W2079220627 creator A5063786040 @default.
- W2079220627 date "1998-05-01" @default.
- W2079220627 modified "2023-10-10" @default.
- W2079220627 title "Retention, Antimicrobial Activity, and Clinical Outcomes Following Use of a Bioerodible Tetracycline Gel in Moderate‐to‐Deep Periodontal Pockets" @default.
- W2079220627 cites W1965450556 @default.
- W2079220627 cites W1976467741 @default.
- W2079220627 cites W1987373761 @default.
- W2079220627 cites W1993551461 @default.
- W2079220627 cites W2003093585 @default.
- W2079220627 cites W2011495086 @default.
- W2079220627 cites W2012133585 @default.
- W2079220627 cites W2022831073 @default.
- W2079220627 cites W2028499573 @default.
- W2079220627 cites W2049213412 @default.
- W2079220627 cites W2057882104 @default.
- W2079220627 cites W2065218351 @default.
- W2079220627 cites W2077503288 @default.
- W2079220627 cites W2087418351 @default.
- W2079220627 cites W2104381799 @default.
- W2079220627 cites W2123545025 @default.
- W2079220627 cites W2152323052 @default.
- W2079220627 cites W2160541575 @default.
- W2079220627 cites W2161897767 @default.
- W2079220627 cites W4255904008 @default.
- W2079220627 cites W4299487820 @default.
- W2079220627 doi "https://doi.org/10.1902/jop.1998.69.5.578" @default.
- W2079220627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9623901" @default.
- W2079220627 hasPublicationYear "1998" @default.
- W2079220627 type Work @default.
- W2079220627 sameAs 2079220627 @default.
- W2079220627 citedByCount "13" @default.
- W2079220627 countsByYear W20792206272017 @default.
- W2079220627 countsByYear W20792206272020 @default.
- W2079220627 crossrefType "journal-article" @default.
- W2079220627 hasAuthorship W2079220627A5018103318 @default.
- W2079220627 hasAuthorship W2079220627A5037840112 @default.
- W2079220627 hasAuthorship W2079220627A5063463731 @default.
- W2079220627 hasAuthorship W2079220627A5063786040 @default.
- W2079220627 hasAuthorship W2079220627A5070714240 @default.
- W2079220627 hasAuthorship W2079220627A5089520411 @default.
- W2079220627 hasConcept C199343813 @default.
- W2079220627 hasConcept C2780035454 @default.
- W2079220627 hasConcept C2780385504 @default.
- W2079220627 hasConcept C2780923616 @default.
- W2079220627 hasConcept C3019361144 @default.
- W2079220627 hasConcept C4937899 @default.
- W2079220627 hasConcept C501593827 @default.
- W2079220627 hasConcept C556039675 @default.
- W2079220627 hasConcept C58747440 @default.
- W2079220627 hasConcept C71924100 @default.
- W2079220627 hasConcept C86803240 @default.
- W2079220627 hasConcept C89423630 @default.
- W2079220627 hasConcept C98274493 @default.
- W2079220627 hasConceptScore W2079220627C199343813 @default.
- W2079220627 hasConceptScore W2079220627C2780035454 @default.
- W2079220627 hasConceptScore W2079220627C2780385504 @default.
- W2079220627 hasConceptScore W2079220627C2780923616 @default.
- W2079220627 hasConceptScore W2079220627C3019361144 @default.
- W2079220627 hasConceptScore W2079220627C4937899 @default.
- W2079220627 hasConceptScore W2079220627C501593827 @default.
- W2079220627 hasConceptScore W2079220627C556039675 @default.
- W2079220627 hasConceptScore W2079220627C58747440 @default.
- W2079220627 hasConceptScore W2079220627C71924100 @default.
- W2079220627 hasConceptScore W2079220627C86803240 @default.
- W2079220627 hasConceptScore W2079220627C89423630 @default.
- W2079220627 hasConceptScore W2079220627C98274493 @default.
- W2079220627 hasIssue "5" @default.
- W2079220627 hasLocation W20792206271 @default.
- W2079220627 hasLocation W20792206272 @default.
- W2079220627 hasOpenAccess W2079220627 @default.
- W2079220627 hasPrimaryLocation W20792206271 @default.
- W2079220627 hasRelatedWork W1587654216 @default.
- W2079220627 hasRelatedWork W1966400051 @default.
- W2079220627 hasRelatedWork W1972980587 @default.
- W2079220627 hasRelatedWork W2006735531 @default.
- W2079220627 hasRelatedWork W2162469627 @default.
- W2079220627 hasRelatedWork W2162819361 @default.
- W2079220627 hasRelatedWork W2394394695 @default.
- W2079220627 hasRelatedWork W2462834055 @default.
- W2079220627 hasRelatedWork W2510778928 @default.
- W2079220627 hasRelatedWork W4240522011 @default.
- W2079220627 hasVolume "69" @default.
- W2079220627 isParatext "false" @default.
- W2079220627 isRetracted "false" @default.
- W2079220627 magId "2079220627" @default.
- W2079220627 workType "article" @default.