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• W2079221326 abstract "Objective: To compare the acceptability, compliance, and effectiveness of two forms of cholestyramine resin in the treatment of hypercholesterolemia in children. Study design: Patients aged 10 to 18 years with familial hypercholesterolemia were enrolled in a randomized, crossover trial of two 8-week periods of either a pill or powder form of cholestyramine at a dose of 8 gm/day. Results: Of 40 children enrolled, 38 completed both medication periods, with a median age of 13 years (range, 10 to 18). At the end of the study, 82% preferred the pill form, 16% the powder form and 2% neither form. Mean (±SD) compliance as assessed by the amount of medication taken was significantly greater for pills (61% ± 31%) than powder (50% ± 30%, p = 0.01). The form of the medication increased compliance by at least 25% for 16 patients (42%), 13 in favor of pills and 3 in favor of powder. Compliance was not associated with patient attitudes and perceptions of hypercholesterolemia, demographics, family history, previous experience with lipid-lowering medication, or lipid profile parameters. Significant mean reductions in low-density lipoprotein cholesterol concentrations were noted for both pills (−10% ± 20%, p = 0.006) and powder (−15% ± 17%, p = 0.0001), with no significant difference between forms ( p = 0.16). Conclusions: A change in bile acid–binding resin formulation from powder to pills significantly increases acceptability and compliance in some children with hypercholesterolemia. (J Pediatr 1997;130:266-73)" @default.
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• W2079221326 date "1997-02-01" @default.
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• W2079221326 title "Acceptability and compliance with two forms of cholestyramine in the treatment of hypercholesterolemia in children: A randomized, crossover trial" @default.
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• W2079221326 doi "https://doi.org/10.1016/s0022-3476(97)70353-6" @default.
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