Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079221454> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2079221454 abstract "Among the many biological characteristics of cancer, the matrix metalloproteinase (MMPs) is essential for tumor invasion and metastasis. The relationship between MMP-2 and MMP-9 according to tumor progression has not been studied yet. We evaluated the synchronous expression and activation rate of MMP-2 and MMP-9 in breast cancer tissues and compared them to the clinical parameters in order to determine the clinical significance of MMPs and the possibilities of using them as a therapeutic target. The activity of MMPs was evaluated in 121 breast cancer tissues using zymography and the area of activation was calculated by computer-assisted densitometry in comparison to the activity of a positive control (HT-1080). In 121 tumor tissues, 32 (26.4%) did not express any form of MMPs and 19 (15.7%) showed both expression of MMP-2 and MMP-9. We observed that only one tissue expressed MMP-9 alone, while MMP-2 alone was expressed in 69 tissues. In 88 patients with MMP-2 and/or MMP-9 expression, we were unable to observe any correlation between the activity of MMPs expression or activation rate and the clinical parameters. But MMP-2 and MMP-9 activity increased according to T factor. Rapid production of MMP-9 occurred from T2 (p=0.046), while that of MMP-2 occurred from T3 (p=0.004). In conclusion, MMPs activity was organ specific. The major MMPs in breast cancer was MMP-2 and MMPs activity was different with tumor progression. When MMPs are a specific therapeutic target, we should use different inhibitors according to tumor size, in patients at the same stage." @default.
- W2079221454 created "2016-06-24" @default.
- W2079221454 creator A5005358526 @default.
- W2079221454 creator A5021404268 @default.
- W2079221454 creator A5024676627 @default.
- W2079221454 creator A5034093287 @default.
- W2079221454 creator A5035238172 @default.
- W2079221454 creator A5040135194 @default.
- W2079221454 creator A5043099056 @default.
- W2079221454 creator A5060446948 @default.
- W2079221454 date "1998-07-01" @default.
- W2079221454 modified "2023-09-26" @default.
- W2079221454 title "Different expression patterns of MMP-2 and MMP-9 in breast cancer." @default.
- W2079221454 doi "https://doi.org/10.3892/or.5.4.875" @default.
- W2079221454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9625836" @default.
- W2079221454 hasPublicationYear "1998" @default.
- W2079221454 type Work @default.
- W2079221454 sameAs 2079221454 @default.
- W2079221454 citedByCount "16" @default.
- W2079221454 countsByYear W20792214542016 @default.
- W2079221454 countsByYear W20792214542019 @default.
- W2079221454 countsByYear W20792214542022 @default.
- W2079221454 crossrefType "journal-article" @default.
- W2079221454 hasAuthorship W2079221454A5005358526 @default.
- W2079221454 hasAuthorship W2079221454A5021404268 @default.
- W2079221454 hasAuthorship W2079221454A5024676627 @default.
- W2079221454 hasAuthorship W2079221454A5034093287 @default.
- W2079221454 hasAuthorship W2079221454A5035238172 @default.
- W2079221454 hasAuthorship W2079221454A5040135194 @default.
- W2079221454 hasAuthorship W2079221454A5043099056 @default.
- W2079221454 hasAuthorship W2079221454A5060446948 @default.
- W2079221454 hasConcept C109523444 @default.
- W2079221454 hasConcept C121608353 @default.
- W2079221454 hasConcept C126322002 @default.
- W2079221454 hasConcept C142724271 @default.
- W2079221454 hasConcept C177430391 @default.
- W2079221454 hasConcept C2776223131 @default.
- W2079221454 hasConcept C2779013556 @default.
- W2079221454 hasConcept C2781018059 @default.
- W2079221454 hasConcept C29537977 @default.
- W2079221454 hasConcept C502942594 @default.
- W2079221454 hasConcept C530470458 @default.
- W2079221454 hasConcept C63363279 @default.
- W2079221454 hasConcept C67082663 @default.
- W2079221454 hasConcept C71924100 @default.
- W2079221454 hasConcept C86803240 @default.
- W2079221454 hasConceptScore W2079221454C109523444 @default.
- W2079221454 hasConceptScore W2079221454C121608353 @default.
- W2079221454 hasConceptScore W2079221454C126322002 @default.
- W2079221454 hasConceptScore W2079221454C142724271 @default.
- W2079221454 hasConceptScore W2079221454C177430391 @default.
- W2079221454 hasConceptScore W2079221454C2776223131 @default.
- W2079221454 hasConceptScore W2079221454C2779013556 @default.
- W2079221454 hasConceptScore W2079221454C2781018059 @default.
- W2079221454 hasConceptScore W2079221454C29537977 @default.
- W2079221454 hasConceptScore W2079221454C502942594 @default.
- W2079221454 hasConceptScore W2079221454C530470458 @default.
- W2079221454 hasConceptScore W2079221454C63363279 @default.
- W2079221454 hasConceptScore W2079221454C67082663 @default.
- W2079221454 hasConceptScore W2079221454C71924100 @default.
- W2079221454 hasConceptScore W2079221454C86803240 @default.
- W2079221454 hasLocation W20792214541 @default.
- W2079221454 hasLocation W20792214542 @default.
- W2079221454 hasOpenAccess W2079221454 @default.
- W2079221454 hasPrimaryLocation W20792214541 @default.
- W2079221454 hasRelatedWork W1485856781 @default.
- W2079221454 hasRelatedWork W1983046502 @default.
- W2079221454 hasRelatedWork W2045345495 @default.
- W2079221454 hasRelatedWork W2052109144 @default.
- W2079221454 hasRelatedWork W2066569455 @default.
- W2079221454 hasRelatedWork W2079194857 @default.
- W2079221454 hasRelatedWork W2079221454 @default.
- W2079221454 hasRelatedWork W2758639219 @default.
- W2079221454 hasRelatedWork W2803841817 @default.
- W2079221454 hasRelatedWork W3173207637 @default.
- W2079221454 isParatext "false" @default.
- W2079221454 isRetracted "false" @default.
- W2079221454 magId "2079221454" @default.
- W2079221454 workType "article" @default.