Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079223774> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2079223774 endingPage "644" @default.
- W2079223774 startingPage "641" @default.
- W2079223774 abstract "The mammalian blood/brain barrier is located at the endothelial cells of the cerebral capillaries. Alkaline phosphatase is associated to a very large extent with these cells and has been established as a marker enzyme for a differentiated blood/brain barrier phenotype in vivo and in vitro. Nevertheless cultured brain capillary endothelial cells (BCEC) lose this marker enzyme because of a cessation of de novo synthesis. Since astrocytes have been shown to possess the capability to re-induce the enzymic activity of alkaline phosphatase in BCEC in vitro we were interested in the second messengers involved in the signal-transduction mechanism of this induction in BCEC. For this reason we treated cultured porcine BCEC with a water-soluble and membrane-permeable analogue of cAMP, 8-(4-chlorophenylthio)-cAMP (ClPhS-cAMP) in the absence of astrocytes. By means of enzymic activity assays we were able to show that within three days the activity of alkaline phosphatase increased up to sixfold compared with the controls. The total activity of alkaline phosphatase in ClPhS-cAMP-treated BCEC was comparable to that of freshly isolated cells. Addition of cycloheximide inhibited the alkaline phosphatase activity increase. We conclude that cAMP is one of the second messengers involved in the induction of alkaline phosphatase activity in BCEC in vitro." @default.
- W2079223774 created "2016-06-24" @default.
- W2079223774 creator A5000919967 @default.
- W2079223774 creator A5055246142 @default.
- W2079223774 creator A5082001516 @default.
- W2079223774 date "2008-06-28" @default.
- W2079223774 modified "2023-09-29" @default.
- W2079223774 title "Induction of the Blood/Brain-Barrier-Associated Enzyme Alkaline Phosphatase in Endothelial Cells from Cerebral Capillaries is Mediated Via cAMP" @default.
- W2079223774 cites W1491060698 @default.
- W2079223774 cites W1966999658 @default.
- W2079223774 cites W1976538215 @default.
- W2079223774 cites W1979632795 @default.
- W2079223774 cites W1980272897 @default.
- W2079223774 cites W1985322186 @default.
- W2079223774 cites W1987641681 @default.
- W2079223774 cites W2005447528 @default.
- W2079223774 cites W2011624699 @default.
- W2079223774 cites W2042963060 @default.
- W2079223774 cites W2047316488 @default.
- W2079223774 cites W2050840761 @default.
- W2079223774 cites W2063991043 @default.
- W2079223774 cites W2065625289 @default.
- W2079223774 cites W2085146964 @default.
- W2079223774 cites W2098400443 @default.
- W2079223774 cites W2104698368 @default.
- W2079223774 cites W2129843133 @default.
- W2079223774 cites W2152353759 @default.
- W2079223774 cites W2199368333 @default.
- W2079223774 cites W4232534952 @default.
- W2079223774 cites W629992290 @default.
- W2079223774 cites W97473470 @default.
- W2079223774 doi "https://doi.org/10.1111/j.1432-1033.1995.0641j.x" @default.
- W2079223774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7758457" @default.
- W2079223774 hasPublicationYear "2008" @default.
- W2079223774 type Work @default.
- W2079223774 sameAs 2079223774 @default.
- W2079223774 citedByCount "10" @default.
- W2079223774 countsByYear W20792237742012 @default.
- W2079223774 countsByYear W20792237742017 @default.
- W2079223774 countsByYear W20792237742018 @default.
- W2079223774 countsByYear W20792237742019 @default.
- W2079223774 countsByYear W20792237742020 @default.
- W2079223774 crossrefType "journal-article" @default.
- W2079223774 hasAuthorship W2079223774A5000919967 @default.
- W2079223774 hasAuthorship W2079223774A5055246142 @default.
- W2079223774 hasAuthorship W2079223774A5082001516 @default.
- W2079223774 hasBestOaLocation W20792237741 @default.
- W2079223774 hasConcept C123012128 @default.
- W2079223774 hasConcept C150903083 @default.
- W2079223774 hasConcept C153911025 @default.
- W2079223774 hasConcept C160160445 @default.
- W2079223774 hasConcept C178666793 @default.
- W2079223774 hasConcept C181199279 @default.
- W2079223774 hasConcept C185592680 @default.
- W2079223774 hasConcept C202751555 @default.
- W2079223774 hasConcept C207001950 @default.
- W2079223774 hasConcept C2778128677 @default.
- W2079223774 hasConcept C3675279 @default.
- W2079223774 hasConcept C55493867 @default.
- W2079223774 hasConcept C62478195 @default.
- W2079223774 hasConcept C86803240 @default.
- W2079223774 hasConcept C95444343 @default.
- W2079223774 hasConceptScore W2079223774C123012128 @default.
- W2079223774 hasConceptScore W2079223774C150903083 @default.
- W2079223774 hasConceptScore W2079223774C153911025 @default.
- W2079223774 hasConceptScore W2079223774C160160445 @default.
- W2079223774 hasConceptScore W2079223774C178666793 @default.
- W2079223774 hasConceptScore W2079223774C181199279 @default.
- W2079223774 hasConceptScore W2079223774C185592680 @default.
- W2079223774 hasConceptScore W2079223774C202751555 @default.
- W2079223774 hasConceptScore W2079223774C207001950 @default.
- W2079223774 hasConceptScore W2079223774C2778128677 @default.
- W2079223774 hasConceptScore W2079223774C3675279 @default.
- W2079223774 hasConceptScore W2079223774C55493867 @default.
- W2079223774 hasConceptScore W2079223774C62478195 @default.
- W2079223774 hasConceptScore W2079223774C86803240 @default.
- W2079223774 hasConceptScore W2079223774C95444343 @default.
- W2079223774 hasIssue "3" @default.
- W2079223774 hasLocation W20792237741 @default.
- W2079223774 hasLocation W20792237742 @default.
- W2079223774 hasOpenAccess W2079223774 @default.
- W2079223774 hasPrimaryLocation W20792237741 @default.
- W2079223774 hasRelatedWork W130010948 @default.
- W2079223774 hasRelatedWork W1549790155 @default.
- W2079223774 hasRelatedWork W1992430433 @default.
- W2079223774 hasRelatedWork W1994748856 @default.
- W2079223774 hasRelatedWork W2009708970 @default.
- W2079223774 hasRelatedWork W2089318461 @default.
- W2079223774 hasRelatedWork W2374599087 @default.
- W2079223774 hasRelatedWork W2400193454 @default.
- W2079223774 hasRelatedWork W2401495086 @default.
- W2079223774 hasRelatedWork W4255217905 @default.
- W2079223774 hasVolume "229" @default.
- W2079223774 isParatext "false" @default.
- W2079223774 isRetracted "false" @default.
- W2079223774 magId "2079223774" @default.
- W2079223774 workType "article" @default.