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• W2079228412 abstract "The DDK syndrome is known as the polar-lethal embryonic death that occurs at the morula-blastocyst stage when female mice of the DDK strain are mated with males from many other inbred strains (alien males). Embryonic death is interpreted to be caused by incompatibility between a DDK oocyte factor and the product from male pronucleus, both of which map to the Om locus on mouse chromosome 11. We compared development of DDK♀×DDK♂ embryos (high viability) and DDK♀ × BALB/c♂ embryos (low viability) before the morula stage (as 2 cell, 4 cell and 8 cell), there was no any morphological manifestations of DDK syndrome are observed. To make sure if the transcripts that are differentially in the DDK♀×BALB/c♂ embryos, we selected a series reference genes such as proto-oncogenes, growth factors, and growth and apoptosis genes and confirmed by quantitative RT-PCR that numbers of genes in those stages are down regulated in the DDK♀×BALB/c♂ embryos. However, except the LIF (leukemia inhibitory factor) was negative expressed and the other genes all detected in three stages. The expression of EGF (epidermal growth factor), EGF-R (epidermal growth factor receptor), Bcl-2 were significant variations (P&#60; 0.01) at the early 4 cell and 8 cell stage, and also the test was significant variations (P&#60;0.01) for the Mcl-1 at all the three stages. Our results indicate that the Om was effected the low-expression of functional genes indirectly to induce embryos destined to die of DDK syndrome and that the embryonic death observed is result of the regulation of multiple genes." @default.
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• W2079228412 date "2011-06-01" @default.
• W2079228412 modified "2023-09-26" @default.
• W2079228412 title "The expression of reference genes affecting preimplantation mouse embryo death in the DDK syndrome" @default.
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• W2079228412 doi "https://doi.org/10.1109/rsete.2011.5966296" @default.
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