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- W2079229052 abstract "Six patients with hyperlipoproteinæmia secondary to the nephrotic syndrome were treated with clofibrate. They were also receiving maintenance diuretic therapy. Muscular pain, stiffness, general malaise, and a pronounced diuresis developed in five of the six patients given clofibrate. Although clofibrate is normally firmly bound to serum-albumin, this investigation revealed that a higher proportion of the clofibrate in the sera of these patients was unbound, and this was responsible for its toxic effects. It is postulated that low serum-albumin reduces the number of binding sites for the drug. Similarly, the diuresis induced in these patients was due to the displacement offrusemide from its albumin-binding site by clofibrate. An increased proportion of unconjugated clofibrate was excreted in the urine of these patients. This may be due to a higher percentage of non-protein-bound clofibrate being excreted or a defect in the glucuronide conjugating mechanism in the kidney. It is recommended that the daily dose of clofibrate used in patients with a low serum-albumin should not exceed 0·5 g. for each 1 g. per 100 ml. of the serum-albumin concentration." @default.
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- W2079229052 title "COMPLICATIONS DURING CLOFIBRATE TREATMENT OF NEPHROTIC-SYNDROME HYPERLIPOPROTEINÆMIA" @default.
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- W2079229052 doi "https://doi.org/10.1016/s0140-6736(72)91905-8" @default.
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