Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079229090> ?p ?o ?g. }
- W2079229090 endingPage "e8815" @default.
- W2079229090 startingPage "e8815" @default.
- W2079229090 abstract "IgG-containing B cell antigen receptor (IgG-BCR), the BCR mostly expressed on memory B cells, contains a distinct signaling function from IgM-BCR or IgD-BCR expressed on naïve B cells. Because naïve B cells transgenic for IgG exhibit augmented response to antigens similar to memory B cells, the distinct signaling function of IgG-BCR appears to play a role in augmented antibody responses of memory B cells. However, how IgG-BCR signaling augments B cell responses is not yet well understood. Here we demonstrate that B cells from IgG-transgenic mice are anergic with defect in generation of BCR signaling upon BCR ligation. However, these IgG-transgenic B cells generate markedly augmented antibody response to a T cell-dependent antigen, probably due to hyper-responsiveness to a T cell-derived signal through CD40. Both BCR signaling defect and augmented response to CD40 ligation are partially restored in xid IgG-transgenic mice in which BCR signaling is down-modulated due to a loss-of-function mutation in the tyrosine kinase Btk crucial for BCR signaling. Thus, IgG-BCR induces augmented B cell responses in the absence of antigen-induced BCR signaling probably through high ligand-independent BCR signaling that may idle B cells to make them ready to respond to T cell help. This finding strongly suggests a crucial role of ligand-independent signaling in receptor function." @default.
- W2079229090 created "2016-06-24" @default.
- W2079229090 creator A5007408242 @default.
- W2079229090 creator A5038094021 @default.
- W2079229090 creator A5078122217 @default.
- W2079229090 creator A5085956653 @default.
- W2079229090 date "2010-01-21" @default.
- W2079229090 modified "2023-09-26" @default.
- W2079229090 title "Augmented B Lymphocyte Response to Antigen in the Absence of Antigen-Induced B Lymphocyte Signaling in an IgG-Transgenic Mouse Line" @default.
- W2079229090 cites W1579796122 @default.
- W2079229090 cites W1587076970 @default.
- W2079229090 cites W1587155866 @default.
- W2079229090 cites W1589053023 @default.
- W2079229090 cites W1630624903 @default.
- W2079229090 cites W1644848712 @default.
- W2079229090 cites W1647622717 @default.
- W2079229090 cites W1669810856 @default.
- W2079229090 cites W1849784454 @default.
- W2079229090 cites W1966949480 @default.
- W2079229090 cites W1971178833 @default.
- W2079229090 cites W1973406789 @default.
- W2079229090 cites W1973640108 @default.
- W2079229090 cites W1975961372 @default.
- W2079229090 cites W1978086285 @default.
- W2079229090 cites W1981027928 @default.
- W2079229090 cites W1984198105 @default.
- W2079229090 cites W1988422289 @default.
- W2079229090 cites W1991988533 @default.
- W2079229090 cites W1996486759 @default.
- W2079229090 cites W2000993160 @default.
- W2079229090 cites W2005862926 @default.
- W2079229090 cites W2023216402 @default.
- W2079229090 cites W2025013345 @default.
- W2079229090 cites W2034271713 @default.
- W2079229090 cites W2045594979 @default.
- W2079229090 cites W2059718955 @default.
- W2079229090 cites W2069076206 @default.
- W2079229090 cites W2070666617 @default.
- W2079229090 cites W2071959150 @default.
- W2079229090 cites W2075657869 @default.
- W2079229090 cites W2078906337 @default.
- W2079229090 cites W2079232338 @default.
- W2079229090 cites W2079633218 @default.
- W2079229090 cites W2081064697 @default.
- W2079229090 cites W2086800018 @default.
- W2079229090 cites W2092579180 @default.
- W2079229090 cites W2092862158 @default.
- W2079229090 cites W2097087970 @default.
- W2079229090 cites W2100212755 @default.
- W2079229090 cites W2102146280 @default.
- W2079229090 cites W2107104928 @default.
- W2079229090 cites W2113237744 @default.
- W2079229090 cites W2115006443 @default.
- W2079229090 cites W2116021132 @default.
- W2079229090 cites W2118650696 @default.
- W2079229090 cites W2119005151 @default.
- W2079229090 cites W2128196707 @default.
- W2079229090 cites W2150783818 @default.
- W2079229090 cites W2151042873 @default.
- W2079229090 cites W2160367702 @default.
- W2079229090 cites W2166265974 @default.
- W2079229090 cites W2167334321 @default.
- W2079229090 cites W2171387990 @default.
- W2079229090 cites W2172393633 @default.
- W2079229090 doi "https://doi.org/10.1371/journal.pone.0008815" @default.
- W2079229090 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2809105" @default.
- W2079229090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20098688" @default.
- W2079229090 hasPublicationYear "2010" @default.
- W2079229090 type Work @default.
- W2079229090 sameAs 2079229090 @default.
- W2079229090 citedByCount "8" @default.
- W2079229090 countsByYear W20792290902012 @default.
- W2079229090 countsByYear W20792290902015 @default.
- W2079229090 countsByYear W20792290902016 @default.
- W2079229090 countsByYear W20792290902018 @default.
- W2079229090 countsByYear W20792290902019 @default.
- W2079229090 countsByYear W20792290902023 @default.
- W2079229090 crossrefType "journal-article" @default.
- W2079229090 hasAuthorship W2079229090A5007408242 @default.
- W2079229090 hasAuthorship W2079229090A5038094021 @default.
- W2079229090 hasAuthorship W2079229090A5078122217 @default.
- W2079229090 hasAuthorship W2079229090A5085956653 @default.
- W2079229090 hasBestOaLocation W20792290901 @default.
- W2079229090 hasConcept C145558887 @default.
- W2079229090 hasConcept C147483822 @default.
- W2079229090 hasConcept C153911025 @default.
- W2079229090 hasConcept C154317977 @default.
- W2079229090 hasConcept C157695867 @default.
- W2079229090 hasConcept C159654299 @default.
- W2079229090 hasConcept C170493617 @default.
- W2079229090 hasConcept C200180986 @default.
- W2079229090 hasConcept C202751555 @default.
- W2079229090 hasConcept C203014093 @default.
- W2079229090 hasConcept C2776090121 @default.
- W2079229090 hasConcept C2777761686 @default.
- W2079229090 hasConcept C2778453870 @default.
- W2079229090 hasConcept C2780898057 @default.
- W2079229090 hasConcept C39347974 @default.