FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079230824> ?p ?o ?g. }

• W2079230824 endingPage "1157" @default.
• W2079230824 startingPage "1149" @default.
• W2079230824 abstract "Leukocyte infiltration in atherosclerosis has been extensively investigated by using histological techniques on fixed tissues. In this study, intravital microscopic observations of leukocyte recruitment in the aorta of atherosclerotic mice were performed. Interactions between leukocytes and atherosclerotic endothelium were highly transient, thereby limiting the ability for rolling leukocytes to firmly adhere. Leukocyte rolling was abolished by function inhibition of P-selectin (P<0.001, n=8), whereas antibody blockage of E-selectin (n=10) decreased rolling leukocyte flux to 51 +/- 9.9% (mean+/-SE, P<0.01) and increased leukocyte rolling velocity to 162 +/- 18% (P<0.01) of pretreatment values. Notably, function inhibition of the integrin alpha(4) subunit (n=5) had no effect on rolling flux (107+/-25%, P=0.782) or rolling velocity (89+/-6.1%, P=0.147), despite endothelial expression of vascular cell adhesion molecule 1 (VCAM-1). Leukocytes interacting with atherosclerotic endothelium were predominantly neutrophils, because treatment with antineutrophil serum decreased rolling and neutrophil counts in peripheral blood to the same extent. In conclusion, we present the first direct observations of atherosclerosis in vivo. We show that transient dynamics of leukocyte-endothelium interactions are important regulators of arterial leukocyte recruitment and that leukocyte rolling in atherosclerosis is critically dependent on the endothelial selectins. This experimental technique and the data presented introduce a novel perspective for the study of pathophysiological events involved in large-vessel disease." @default.
• W2079230824 created "2016-06-24" @default.
• W2079230824 creator A5001317605 @default.
• W2079230824 creator A5011548115 @default.
• W2079230824 creator A5059101867 @default.
• W2079230824 creator A5076262440 @default.
• W2079230824 creator A5078090039 @default.
• W2079230824 date "2001-05-01" @default.
• W2079230824 modified "2023-10-15" @default.
• W2079230824 title "Direct viewing of atherosclerosis in vivo: plaque invasion by leukocytes is initiated by the endothelial selectins" @default.
• W2079230824 cites W1564695791 @default.
• W2079230824 cites W1661430296 @default.
• W2079230824 cites W1920517630 @default.
• W2079230824 cites W1971444570 @default.
• W2079230824 cites W2008351843 @default.
• W2079230824 cites W2013739288 @default.
• W2079230824 cites W2047522378 @default.
• W2079230824 cites W2055083588 @default.
• W2079230824 cites W2057456916 @default.
• W2079230824 cites W2057627593 @default.
• W2079230824 cites W2074253462 @default.
• W2079230824 cites W2079926187 @default.
• W2079230824 cites W2083217753 @default.
• W2079230824 cites W2099675490 @default.
• W2079230824 cites W2100709790 @default.
• W2079230824 cites W2100937166 @default.
• W2079230824 cites W2106131101 @default.
• W2079230824 cites W2107060621 @default.
• W2079230824 cites W2114704077 @default.
• W2079230824 cites W2117127822 @default.
• W2079230824 cites W2131325466 @default.
• W2079230824 cites W2136147428 @default.
• W2079230824 cites W2147204790 @default.
• W2079230824 cites W2148599633 @default.
• W2079230824 cites W2148792638 @default.
• W2079230824 cites W2163125145 @default.
• W2079230824 cites W2171312363 @default.
• W2079230824 cites W2187896211 @default.
• W2079230824 cites W2259392365 @default.
• W2079230824 cites W2324841714 @default.
• W2079230824 doi "https://doi.org/10.1096/fj.00-0537com" @default.
• W2079230824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11344083" @default.
• W2079230824 hasPublicationYear "2001" @default.
• W2079230824 type Work @default.
• W2079230824 sameAs 2079230824 @default.
• W2079230824 citedByCount "121" @default.
• W2079230824 countsByYear W20792308242012 @default.
• W2079230824 countsByYear W20792308242013 @default.
• W2079230824 countsByYear W20792308242014 @default.
• W2079230824 countsByYear W20792308242015 @default.
• W2079230824 countsByYear W20792308242016 @default.
• W2079230824 countsByYear W20792308242017 @default.
• W2079230824 countsByYear W20792308242018 @default.
• W2079230824 countsByYear W20792308242019 @default.
• W2079230824 countsByYear W20792308242020 @default.
• W2079230824 countsByYear W20792308242021 @default.
• W2079230824 countsByYear W20792308242022 @default.
• W2079230824 countsByYear W20792308242023 @default.
• W2079230824 crossrefType "journal-article" @default.
• W2079230824 hasAuthorship W2079230824A5001317605 @default.
• W2079230824 hasAuthorship W2079230824A5011548115 @default.
• W2079230824 hasAuthorship W2079230824A5059101867 @default.
• W2079230824 hasAuthorship W2079230824A5076262440 @default.
• W2079230824 hasAuthorship W2079230824A5078090039 @default.
• W2079230824 hasConcept C10162356 @default.
• W2079230824 hasConcept C121332964 @default.
• W2079230824 hasConcept C123012128 @default.
• W2079230824 hasConcept C126322002 @default.
• W2079230824 hasConcept C142724271 @default.
• W2079230824 hasConcept C1491633281 @default.
• W2079230824 hasConcept C150903083 @default.
• W2079230824 hasConcept C153400128 @default.
• W2079230824 hasConcept C155619193 @default.
• W2079230824 hasConcept C16224149 @default.
• W2079230824 hasConcept C185592680 @default.
• W2079230824 hasConcept C195687474 @default.
• W2079230824 hasConcept C202751555 @default.
• W2079230824 hasConcept C203014093 @default.
• W2079230824 hasConcept C207001950 @default.
• W2079230824 hasConcept C2776914184 @default.
• W2079230824 hasConcept C2776992346 @default.
• W2079230824 hasConcept C2779980429 @default.
• W2079230824 hasConcept C2859252 @default.
• W2079230824 hasConcept C3018697912 @default.
• W2079230824 hasConcept C55493867 @default.
• W2079230824 hasConcept C56701166 @default.
• W2079230824 hasConcept C71924100 @default.
• W2079230824 hasConcept C86803240 @default.
• W2079230824 hasConcept C89560881 @default.
• W2079230824 hasConcept C97355855 @default.
• W2079230824 hasConceptScore W2079230824C10162356 @default.
• W2079230824 hasConceptScore W2079230824C121332964 @default.
• W2079230824 hasConceptScore W2079230824C123012128 @default.
• W2079230824 hasConceptScore W2079230824C126322002 @default.
• W2079230824 hasConceptScore W2079230824C142724271 @default.
• W2079230824 hasConceptScore W2079230824C1491633281 @default.
• W2079230824 hasConceptScore W2079230824C150903083 @default.
• W2079230824 hasConceptScore W2079230824C153400128 @default.

• next