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• W2079231006 abstract "A new poly-aggregated form of amphotericin B was formulated as a non-microencapsulated form (P-AMB) or incorporated in albumin microspheres (MP-AMB) and compared with the conventional amphotericin B formulation (D-AMB). Mice were infected with Candida albicans and treated with two different intermittent dose regimens of the different amphotericin B formulations. Efficacy and toxicity were studied by the determination of survival rate, kidney colony-forming units counts, biochemical parameters and amphotericin B concentrations in plasma and organs. All the treatments significantly ( P < 0.05) increased the survival rate in relation to the untreated group, although non-statistically significant differences ( P > 0.05) were found between formulations and dosing regimens. All the treatments produced kidney toxicity, expressed by high urea levels. Kidney toxicity was especially significant for mice treated with the D-AMB formulation where unilateral kidney atrophy was observed in most of the mice, whereas most of the mice treated with P-AMB conserved both kidneys with a normal size and appearance. At 45 days post infection, variable distribution of amphotericin B in the body was obtained depending on the amphotericin B formulation. In conclusion, non-daily dosing regimens of P-AMB, which is less toxic than D-AMB, could be used as an alternative to the conventional D-AMB formulation to treat experimental candidiasis." @default.
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• W2079231006 date "2008-07-01" @default.
• W2079231006 modified "2023-10-01" @default.
• W2079231006 title "Efficacy of alternative dosing regimens of poly-aggregated amphotericin B" @default.
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• W2079231006 doi "https://doi.org/10.1016/j.ijantimicag.2008.02.025" @default.
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