Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079231229> ?p ?o ?g. }
- W2079231229 endingPage "172" @default.
- W2079231229 startingPage "135" @default.
- W2079231229 abstract "Parkinson's disease (PD) is a neurodegenerative disorder characterized by a preferential loss of the dopaminergic neurons of the substantia nigra pars compacta. Although the etiology of PD is unknown, major biochemical processes such as oxidative stress and mitochondrial inhibition are largely described. However, despite these findings, the actual therapeutics are essentially symptomatical and are not able to block the degenerative process. Recent histological studies performed on brains from PD patients suggest that nigral cell death could be apoptotic. However, since post-mortem studies do not allow precise determination of the sequence of events leading to this apoptotic cell death, the molecular pathways involved in this process have been essentially studied on experimental models reproducing the human disease. These latter are created by using neurotoxic compounds such as 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or dopamine (DA). Extensive study of these models have shown that they mimick, in vitro and in vivo, the histological and/or the biochemical characteristics of PD and thus help to define important cellular actors of cell death presumably critical for the nigral degeneration. This review reports recent data concerning the biochemical and molecular apoptotic mechanisms underlying the experimental models of PD and correlates them to the phenomena occurring in human disease." @default.
- W2079231229 created "2016-06-24" @default.
- W2079231229 creator A5046120622 @default.
- W2079231229 creator A5046585367 @default.
- W2079231229 creator A5053472629 @default.
- W2079231229 creator A5062355026 @default.
- W2079231229 creator A5076634940 @default.
- W2079231229 creator A5082794092 @default.
- W2079231229 creator A5084603865 @default.
- W2079231229 date "2001-10-01" @default.
- W2079231229 modified "2023-10-15" @default.
- W2079231229 title "Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease" @default.
- W2079231229 cites W107210068 @default.
- W2079231229 cites W1490480018 @default.
- W2079231229 cites W1501301649 @default.
- W2079231229 cites W1501428936 @default.
- W2079231229 cites W1504584187 @default.
- W2079231229 cites W1505206211 @default.
- W2079231229 cites W1508761934 @default.
- W2079231229 cites W1513688899 @default.
- W2079231229 cites W1515578871 @default.
- W2079231229 cites W1515821225 @default.
- W2079231229 cites W1527671059 @default.
- W2079231229 cites W1531843401 @default.
- W2079231229 cites W1542061701 @default.
- W2079231229 cites W1542569132 @default.
- W2079231229 cites W1544063520 @default.
- W2079231229 cites W1548033063 @default.
- W2079231229 cites W1548815964 @default.
- W2079231229 cites W1549081254 @default.
- W2079231229 cites W1568529372 @default.
- W2079231229 cites W1572174728 @default.
- W2079231229 cites W1594281994 @default.
- W2079231229 cites W1602098835 @default.
- W2079231229 cites W1602356478 @default.
- W2079231229 cites W1605767786 @default.
- W2079231229 cites W1606295911 @default.
- W2079231229 cites W1621509181 @default.
- W2079231229 cites W1627593641 @default.
- W2079231229 cites W1680974060 @default.
- W2079231229 cites W175006040 @default.
- W2079231229 cites W1796430339 @default.
- W2079231229 cites W1877873625 @default.
- W2079231229 cites W189994567 @default.
- W2079231229 cites W1904788586 @default.
- W2079231229 cites W1904882776 @default.
- W2079231229 cites W1911240597 @default.
- W2079231229 cites W1942214720 @default.
- W2079231229 cites W1945304257 @default.
- W2079231229 cites W1946022517 @default.
- W2079231229 cites W1946523045 @default.
- W2079231229 cites W1950372811 @default.
- W2079231229 cites W1964230438 @default.
- W2079231229 cites W1964517676 @default.
- W2079231229 cites W1964617786 @default.
- W2079231229 cites W1964671322 @default.
- W2079231229 cites W1965006448 @default.
- W2079231229 cites W1965122438 @default.
- W2079231229 cites W1965575645 @default.
- W2079231229 cites W1966778168 @default.
- W2079231229 cites W1967196887 @default.
- W2079231229 cites W1967918036 @default.
- W2079231229 cites W1968015127 @default.
- W2079231229 cites W1968054339 @default.
- W2079231229 cites W1968576323 @default.
- W2079231229 cites W1968786165 @default.
- W2079231229 cites W1969188373 @default.
- W2079231229 cites W1969291345 @default.
- W2079231229 cites W1969331809 @default.
- W2079231229 cites W1969439696 @default.
- W2079231229 cites W1969800514 @default.
- W2079231229 cites W1970325298 @default.
- W2079231229 cites W1970534639 @default.
- W2079231229 cites W1972108431 @default.
- W2079231229 cites W1972278524 @default.
- W2079231229 cites W1972301751 @default.
- W2079231229 cites W1972436933 @default.
- W2079231229 cites W1973415486 @default.
- W2079231229 cites W1973518232 @default.
- W2079231229 cites W1973541476 @default.
- W2079231229 cites W1974147892 @default.
- W2079231229 cites W1974924674 @default.
- W2079231229 cites W1974980101 @default.
- W2079231229 cites W1975787195 @default.
- W2079231229 cites W1976316003 @default.
- W2079231229 cites W1976385326 @default.
- W2079231229 cites W1977314903 @default.
- W2079231229 cites W1977575797 @default.
- W2079231229 cites W1977817124 @default.
- W2079231229 cites W1978559408 @default.
- W2079231229 cites W1978926564 @default.
- W2079231229 cites W1979054164 @default.
- W2079231229 cites W1979176029 @default.
- W2079231229 cites W1979453854 @default.
- W2079231229 cites W1979664185 @default.
- W2079231229 cites W1979686914 @default.
- W2079231229 cites W1979814082 @default.
- W2079231229 cites W1980508665 @default.