FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079232151> ?p ?o ?g. }

• W2079232151 endingPage "301" @default.
• W2079232151 startingPage "290" @default.
• W2079232151 abstract "Dialysis-induced hypotension has received considerable attention recently because of its high incidence of occurrence. Several factors have been proposed as etiologic mechanisms. They include hypovolemia, autonomic dysfunction, decreasing serum osmolality, vasodilation (or the inhibition of compensatory vasoconstriction), efficiency of diffusive solute transport, depletion of vasoactive substances and blood gas and acid-base changes. The primary determinants of blood pressure being cardiac output and total peripheral resistance, the magnitude and direction of change of these two parameters determines the blood pressure response. If the rate of ultrafiltration exceeds the rate of vascular refilling, hypovolemia results. Intracellular fluid shifts secondary to preferential solute removal from the extracellular space may compromise vascular refilling and contribute to hypovolemia. If the hypovolemia is not compensated for by increases in heart rate or stroke volume, the cardiac output falls. Autonomic dysfunction, a previous history of myocardial infarction or impaired tissue oxygenation secondary to hypoxia may limit compensatory increases in heart rate and stroke volume. Even if the cardiac output falls, if compensatory vasoconstriction is elicited, blood pressure can be maintained. The experimental evidence suggests that the diffusive aspect of dialysis therapy plays an important role in inhibiting compensatory vasoconstriction. Such inhibition is not observed with hemofiltration, a therapy based on convective rather than diffusive solute removal. While autonomic dysfunction and the diffusive removal of vasoactive substances may play a role in inhibiting the vasoconstrictive response, the use of acetate as a buffer source and the decreasing serum osmolality seem to be of greater importance. Acetate produces vasodilation. It also has a positive inotropic effect. Studies suggest that the vasodilation produced by acetate is compensated for by a proportionate increase in cardiac output except during the early stages of the therapy when the fall in total peripheral resistance may overwhelm the increase in cardiac output. The substitution of bicarbonate for acetate results in a decrease in the incidence of symptomatic hypotension in some patients. This alleviation of symptoms appears to be significant only when the dialystate sodium concentration is relatively low (130–135 m M ). At higher dialysate sodium concentrations (140–145 m M ), the blunting of the fall in serum osmolality seems to be of greater importance than the nature of the buffer source in reducing the incidence of symptomatic hypotension. It is not clear if blunting the fall in serum osmolality has a greater beneficial influence on the cardiac output or on the total peripheral resistance. While the etiology of dialysis-induced hypotension is complex, controversial, and multifactorial, amelioration of symptomatic hypotension with a higher dialysate sodium concentration offers a practical solution. The substitution of bicarbonate for acetate is a technically more complex and expensive alternative." @default.
• W2079232151 created "2016-06-24" @default.
• W2079232151 creator A5051707990 @default.
• W2079232151 creator A5066976153 @default.
• W2079232151 date "1982-09-01" @default.
• W2079232151 modified "2023-09-26" @default.
• W2079232151 title "A Critical Examination of Dialysis-Induced Hypotension" @default.
• W2079232151 cites W1490919056 @default.
• W2079232151 cites W1963709752 @default.
• W2079232151 cites W1965654099 @default.
• W2079232151 cites W1965887484 @default.
• W2079232151 cites W1970777597 @default.
• W2079232151 cites W1970801707 @default.
• W2079232151 cites W1974203272 @default.
• W2079232151 cites W1975931231 @default.
• W2079232151 cites W1976325093 @default.
• W2079232151 cites W1977162199 @default.
• W2079232151 cites W1998199752 @default.
• W2079232151 cites W2005197932 @default.
• W2079232151 cites W2023494518 @default.
• W2079232151 cites W2036202804 @default.
• W2079232151 cites W2043269899 @default.
• W2079232151 cites W2060166537 @default.
• W2079232151 cites W2091077342 @default.
• W2079232151 cites W2091981147 @default.
• W2079232151 cites W2329679831 @default.
• W2079232151 cites W2399909043 @default.
• W2079232151 cites W2400118944 @default.
• W2079232151 cites W2405957317 @default.
• W2079232151 cites W2409031096 @default.
• W2079232151 cites W2409043977 @default.
• W2079232151 cites W2410077918 @default.
• W2079232151 cites W2410312911 @default.
• W2079232151 cites W2410619943 @default.
• W2079232151 cites W2410747578 @default.
• W2079232151 cites W2411053679 @default.
• W2079232151 cites W2411088696 @default.
• W2079232151 cites W2411811929 @default.
• W2079232151 cites W2412349488 @default.
• W2079232151 cites W2412828121 @default.
• W2079232151 cites W2413278471 @default.
• W2079232151 cites W2413466727 @default.
• W2079232151 cites W2415136719 @default.
• W2079232151 cites W2418677188 @default.
• W2079232151 cites W2419045540 @default.
• W2079232151 cites W2419660906 @default.
• W2079232151 cites W2423600002 @default.
• W2079232151 cites W2428014813 @default.
• W2079232151 cites W2461467105 @default.
• W2079232151 cites W2465268731 @default.
• W2079232151 cites W2465506033 @default.
• W2079232151 cites W2467711512 @default.
• W2079232151 cites W2473707495 @default.
• W2079232151 cites W3143311813 @default.
• W2079232151 cites W6969217 @default.
• W2079232151 cites W2412263363 @default.
• W2079232151 doi "https://doi.org/10.1016/s0272-6386(82)80078-4" @default.
• W2079232151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7124728" @default.
• W2079232151 hasPublicationYear "1982" @default.
• W2079232151 type Work @default.
• W2079232151 sameAs 2079232151 @default.
• W2079232151 citedByCount "50" @default.
• W2079232151 countsByYear W20792321512016 @default.
• W2079232151 crossrefType "journal-article" @default.
• W2079232151 hasAuthorship W2079232151A5051707990 @default.
• W2079232151 hasAuthorship W2079232151A5066976153 @default.
• W2079232151 hasConcept C126322002 @default.
• W2079232151 hasConcept C177713679 @default.
• W2079232151 hasConcept C2779978075 @default.
• W2079232151 hasConcept C71924100 @default.
• W2079232151 hasConceptScore W2079232151C126322002 @default.
• W2079232151 hasConceptScore W2079232151C177713679 @default.
• W2079232151 hasConceptScore W2079232151C2779978075 @default.
• W2079232151 hasConceptScore W2079232151C71924100 @default.
• W2079232151 hasIssue "2" @default.
• W2079232151 hasLocation W20792321511 @default.
• W2079232151 hasLocation W20792321512 @default.
• W2079232151 hasOpenAccess W2079232151 @default.
• W2079232151 hasPrimaryLocation W20792321511 @default.
• W2079232151 hasRelatedWork W1595295090 @default.
• W2079232151 hasRelatedWork W1996070763 @default.
• W2079232151 hasRelatedWork W2012022070 @default.
• W2079232151 hasRelatedWork W2044363095 @default.
• W2079232151 hasRelatedWork W2166754894 @default.
• W2079232151 hasRelatedWork W2401909931 @default.
• W2079232151 hasRelatedWork W2415504834 @default.
• W2079232151 hasRelatedWork W2996539601 @default.
• W2079232151 hasRelatedWork W4252371801 @default.
• W2079232151 hasRelatedWork W4253571272 @default.
• W2079232151 hasVolume "2" @default.
• W2079232151 isParatext "false" @default.
• W2079232151 isRetracted "false" @default.
• W2079232151 magId "2079232151" @default.
• W2079232151 workType "article" @default.