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• W2079232912 endingPage "1915" @default.
• W2079232912 startingPage "1899" @default.
• W2079232912 abstract "Enkephalin has been demonstrated in neurones in organotypic cultures of embryonic rat lumbar spinal cord using the indirect immunofluorescence technique. The peptide was demonstrated in neurone precursors in cultures of spinal cord at stage 16 (10 days' gestation). The subsequent development of the cells was studied by culturing spinal cord tissue from stage 30–34 (14–17 days' gestation) embryos and applying sequential immunocytochemistry, silver impregnation histology and autoradiography to the preparations. Acetylcholinesterase and γ-aminobutyrate transaminase activity in neurones and fibres in stage 30–34 cultures was at a maximum three weeks after explantation. Following a 24 h pulse of [3H]thymidine, about one third of enkephalin-immunoreactive neurones were labelled in cultures 7 days old. The proportion fell to nearly zero in cultures 14 and 21 days old. At this time axonal and dendritic growth began in most immunoreactive cells. The disappearance of neuritic growth cones indicated that differentiation of the cells was not complete until 5–7 weeks after explanation. Fully-differentiated neurones had cell bodies of 10–15 μm diameter and processes spanning 400 μm or less. During development and at maturity, three groups of immunoreactive neurone were identified by morphological criteria. Immunocytochemical demonstration of leucine enkephalin-containing neurones in smear preparations of spinal cord from young animals suggested that their cytodifferentiation was also completed late in the process of development in vivo (after the second week of life). The results show that lumbar spinal neurones containing the putative transmitter, leucine enkephalin, have a prolonged but otherwise normal pattern of development when grown in tissue culture. When mature they appear to be small interneurones of several morphological types." @default.
• W2079232912 created "2016-06-24" @default.
• W2079232912 creator A5079528416 @default.
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• W2079232912 date "1981-10-01" @default.
• W2079232912 modified "2023-09-26" @default.
• W2079232912 title "Microanatomy of enkephalin-containing neurones in the developing rat spinal cordin vitro" @default.
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• W2079232912 doi "https://doi.org/10.1016/0306-4522(81)90030-0" @default.
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