Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079234345> ?p ?o ?g. }
- W2079234345 endingPage "e30379" @default.
- W2079234345 startingPage "e30379" @default.
- W2079234345 abstract "Chlamydophila pneumoniae causes acute respiratory tract infections and has been associated with development of asthma and atherosclerosis. The production of IL-1β, a key mediator of acute and chronic inflammation, is regulated on a transcriptional level and additionally on a posttranslational level by inflammasomes. In the present study we show that C. pneumoniae-infected human mononuclear cells produce IL-1β protein depending on an inflammasome consisting of NLRP3, the adapter protein ASC and caspase-1. We further found that the small GTPase Rac1 is activated in C. pneumoniae-infected cells. Importantly, studies with specific inhibitors as well as siRNA show that Rac1 regulates inflammasome activation in C. pneumoniae-infected cells. In conclusion, C. pneumoniae infection of mononuclear cells stimulates IL-1β production dependent on a NLRP3 inflammasome-mediated processing of proIL-1β which is controlled by Rac1." @default.
- W2079234345 created "2016-06-24" @default.
- W2079234345 creator A5006539968 @default.
- W2079234345 creator A5009738279 @default.
- W2079234345 creator A5016267636 @default.
- W2079234345 creator A5017328820 @default.
- W2079234345 creator A5019841125 @default.
- W2079234345 creator A5021026009 @default.
- W2079234345 creator A5031735316 @default.
- W2079234345 creator A5040973193 @default.
- W2079234345 creator A5045133691 @default.
- W2079234345 creator A5064281779 @default.
- W2079234345 date "2012-01-20" @default.
- W2079234345 modified "2023-10-18" @default.
- W2079234345 title "Rac1 Regulates the NLRP3 Inflammasome Which Mediates IL-1beta Production in Chlamydophila pneumoniae Infected Human Mononuclear Cells" @default.
- W2079234345 cites W10482017 @default.
- W2079234345 cites W1481916388 @default.
- W2079234345 cites W1511950293 @default.
- W2079234345 cites W1534378060 @default.
- W2079234345 cites W1743744546 @default.
- W2079234345 cites W1899835135 @default.
- W2079234345 cites W1901112902 @default.
- W2079234345 cites W1939473967 @default.
- W2079234345 cites W1964048031 @default.
- W2079234345 cites W1974389984 @default.
- W2079234345 cites W1979991507 @default.
- W2079234345 cites W1984607094 @default.
- W2079234345 cites W2009423065 @default.
- W2079234345 cites W2009800174 @default.
- W2079234345 cites W2009942981 @default.
- W2079234345 cites W2020588519 @default.
- W2079234345 cites W2021068575 @default.
- W2079234345 cites W2028789055 @default.
- W2079234345 cites W2033905783 @default.
- W2079234345 cites W2039010779 @default.
- W2079234345 cites W2041012906 @default.
- W2079234345 cites W2042433863 @default.
- W2079234345 cites W2045953344 @default.
- W2079234345 cites W2047385065 @default.
- W2079234345 cites W2047453903 @default.
- W2079234345 cites W2051714701 @default.
- W2079234345 cites W2055408817 @default.
- W2079234345 cites W2077792958 @default.
- W2079234345 cites W2079977909 @default.
- W2079234345 cites W2082293908 @default.
- W2079234345 cites W2085128107 @default.
- W2079234345 cites W2090859543 @default.
- W2079234345 cites W2095562167 @default.
- W2079234345 cites W2096785904 @default.
- W2079234345 cites W2096791952 @default.
- W2079234345 cites W2097825875 @default.
- W2079234345 cites W2103358704 @default.
- W2079234345 cites W2105108345 @default.
- W2079234345 cites W2108527091 @default.
- W2079234345 cites W2114769428 @default.
- W2079234345 cites W2120062351 @default.
- W2079234345 cites W2126384811 @default.
- W2079234345 cites W2127453904 @default.
- W2079234345 cites W2128021591 @default.
- W2079234345 cites W2134302845 @default.
- W2079234345 cites W2138626623 @default.
- W2079234345 cites W2139248214 @default.
- W2079234345 cites W2140509694 @default.
- W2079234345 cites W2147978858 @default.
- W2079234345 cites W2150086428 @default.
- W2079234345 cites W2151713498 @default.
- W2079234345 cites W2155138367 @default.
- W2079234345 cites W2155983915 @default.
- W2079234345 cites W2162930456 @default.
- W2079234345 cites W2165549236 @default.
- W2079234345 doi "https://doi.org/10.1371/journal.pone.0030379" @default.
- W2079234345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3262829" @default.
- W2079234345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22276187" @default.
- W2079234345 hasPublicationYear "2012" @default.
- W2079234345 type Work @default.
- W2079234345 sameAs 2079234345 @default.
- W2079234345 citedByCount "37" @default.
- W2079234345 countsByYear W20792343452012 @default.
- W2079234345 countsByYear W20792343452013 @default.
- W2079234345 countsByYear W20792343452014 @default.
- W2079234345 countsByYear W20792343452015 @default.
- W2079234345 countsByYear W20792343452016 @default.
- W2079234345 countsByYear W20792343452017 @default.
- W2079234345 countsByYear W20792343452018 @default.
- W2079234345 countsByYear W20792343452019 @default.
- W2079234345 countsByYear W20792343452020 @default.
- W2079234345 countsByYear W20792343452021 @default.
- W2079234345 countsByYear W20792343452022 @default.
- W2079234345 crossrefType "journal-article" @default.
- W2079234345 hasAuthorship W2079234345A5006539968 @default.
- W2079234345 hasAuthorship W2079234345A5009738279 @default.
- W2079234345 hasAuthorship W2079234345A5016267636 @default.
- W2079234345 hasAuthorship W2079234345A5017328820 @default.
- W2079234345 hasAuthorship W2079234345A5019841125 @default.
- W2079234345 hasAuthorship W2079234345A5021026009 @default.
- W2079234345 hasAuthorship W2079234345A5031735316 @default.
- W2079234345 hasAuthorship W2079234345A5040973193 @default.
- W2079234345 hasAuthorship W2079234345A5045133691 @default.