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- W2079235795 abstract "Previous investigations of the effects of potent opioid analgesics on the heart have concentrated on effects on contraction magnitude and time course, but little is known about their effects on cytosolic Ca 2 regulation in cardiac tissue. In this study, we sought to assess the effects of alfentanil on contractility and the cytosolic Ca 2 transient in ventricular myocytes isolated from the rat ventricle by enzymatic dispersion. Cells were loaded with fura-2 and electrically stimulated at 1 Hz, and Ca 2 transients and contractions were recorded optically at 30°C. Alfentanil 10 8 and 10 7 M had no effect on the magnitude or time course of contraction or the cytosolic Ca 2 transient. In contrast, 10 6 M alfentanil induced a significant (P 0.001) positive inotropic effect, increasing the mean (sem) unloaded shortening from 7.3 1.3 mt o 8.7 1.4m (an increase of 20%), with no change in the cytosolic Ca 2 transient. Myofilament Ca 2 sensitivity was significantly (P 0.027) increased by 10 6 M alfentanil but unaffected at 10 7 M alfentanil. These data show that 10 6 M alfentanil, a concentration close to the maximum clinical free plasma concentration, induced a positive inotropic effect due to sensitization of the myofilaments to Ca 2 rather than to modified cytosolic Ca 2 regulation." @default.
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- W2079235795 date "2004-04-01" @default.
- W2079235795 modified "2023-10-14" @default.
- W2079235795 title "The Effects of Alfentanil on Cytosolic Ca2+ and Contraction in Rat Ventricular Myocytes" @default.
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- W2079235795 doi "https://doi.org/10.1213/01.ane.0000104481.20813.35" @default.
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