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- W2079235989 abstract "To study the role of CD40 ligand (CD40L) in the host immune responses against intracellular pathogens, we infected CD40L knockout (CD40L−/−) mice with Leishmania amazonensis. Although wild-type mice were susceptible to infection and developed progressive ulcerative lesions, tissue parasite burdens in CD40L−/− mice were significantly higher. This heightened susceptibility to infection was associated with an impaired T cell and macrophage activation and altered inflammatory response, as reflected by low levels of IFNγ, lymphotoxin–tumor necrosis factor (LT–TNF), and nitric oxide (NO) production. Furthermore, CD40L−/− mice failed to generate a protective immune response after immunization. These results indicate an essential role of cognate CD40–CD40L interactions in the generation of cellular immune responses against an intracellular parasite." @default.
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- W2079235989 date "1996-03-01" @default.
- W2079235989 modified "2023-09-23" @default.
- W2079235989 title "Disruption of CD40–CD40 Ligand Interactions Results in an Enhanced Susceptibility to Leishmania amazonensis Infection" @default.
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- W2079235989 doi "https://doi.org/10.1016/s1074-7613(00)80434-3" @default.
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