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- W2079236334 abstract "Induction of transplantation tolerance has the potential to allow for allograft acceptance without the need for life-long immunosuppression. Here we describe a novel approach that uses delivery of alloantigen by mature T cells to induce tolerance to fully allogeneic cardiac grafts. Adoptive transfer of mature alloantigen-expressing T cells into myeloablatively conditioned mice results in long-term acceptance of fully allogeneic heart transplants without evidence of chronic rejection. Since myeloablative conditioning is clinically undesirable we further demonstrated that adoptive transfer of mature alloantigen-expressing T cells alone into mice receiving non-myeloablative conditioning resulted in long-term acceptance of fully allogeneic heart allografts with minimal evidence of chronic rejection. Mechanistically, tolerance induction involved both deletion of donor-reactive host T cells and the development of regulatory T cells. Thus, delivery of alloantigen by mature T cells induces tolerance to fully allogeneic organ allografts in non-myeloablatively conditioned recipients, representing a novel approach for tolerance induction in transplantation." @default.
- W2079236334 created "2016-06-24" @default.
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- W2079236334 date "2010-08-01" @default.
- W2079236334 modified "2023-09-22" @default.
- W2079236334 title "Induction of transplantation tolerance to fully mismatched cardiac allografts by T cell mediated delivery of alloantigen" @default.
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- W2079236334 doi "https://doi.org/10.1016/j.clim.2010.04.012" @default.
- W2079236334 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2991109" @default.
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