Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079236410> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2079236410 endingPage "891" @default.
- W2079236410 startingPage "887" @default.
- W2079236410 abstract "Nociceptin, also referred to as orphanin FQ, is believed to be the endogenous ligand for the ORL1. 8, 9, 12Nociceptin, when injected intracerebroventricularly to mice, produced hyperalgesia in behavioral tests.8, 12Recent studies have demonstrated the presence of ORL1 transcript in the spinal cord, and ORL1-like immunoreactivity has been localized to nerve fibers and somata throughout the spinal cord.1, 16Here, we report the localization of nociceptin-like immunoreactivity to fiber-like elements of the superficial layers of the rat dorsal horn by immunohistochemical techniques. Whole-cell recordings from substantia gelatinosa neurons in transverse lumbar spinal cord slices of 22–26-day-old rats showed that erogenous nociceptin at low concentrations (100–300 nM) depressed excitatory postsynaptic potentials evoked by stimulation of dorsal rootlets without causing an appreciable change of resting membrane potentials and glutamate-evoked depolarizations. At a concentration of 1 μM, nociceptin hyperpolarized substantia gelatinosa neurons and suppressed spike discharges. The hyperpolarizing and synaptic depressant action of nociceptin was not reversed by the known opioid receptor antagonist naloxone (1 μM). Our result provides evidence that nociceptin-like peptide is concentrated in nerve fibers of the rat dorsal horn and that it may serve as an inhibitory transmitter within the substantia gelatinosa." @default.
- W2079236410 created "2016-06-24" @default.
- W2079236410 creator A5009368307 @default.
- W2079236410 creator A5037190018 @default.
- W2079236410 creator A5047231135 @default.
- W2079236410 creator A5088941725 @default.
- W2079236410 date "1997-10-01" @default.
- W2079236410 modified "2023-09-24" @default.
- W2079236410 title "Nociceptin-like immunoreactivity in the rat dorsal horn and inhibition of substantia gelatinosa neurons" @default.
- W2079236410 cites W1598044684 @default.
- W2079236410 cites W1983247308 @default.
- W2079236410 cites W2016562510 @default.
- W2079236410 cites W2026594079 @default.
- W2079236410 cites W2031961444 @default.
- W2079236410 cites W2045129357 @default.
- W2079236410 cites W2047065455 @default.
- W2079236410 cites W2053243081 @default.
- W2079236410 cites W2054681335 @default.
- W2079236410 cites W2064228594 @default.
- W2079236410 cites W2064319342 @default.
- W2079236410 cites W2066624199 @default.
- W2079236410 cites W2066816450 @default.
- W2079236410 cites W2070034006 @default.
- W2079236410 cites W2077191265 @default.
- W2079236410 cites W2091459134 @default.
- W2079236410 cites W2124787044 @default.
- W2079236410 cites W2129360860 @default.
- W2079236410 cites W2396465973 @default.
- W2079236410 doi "https://doi.org/10.1016/s0306-4522(97)00251-0" @default.
- W2079236410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9330354" @default.
- W2079236410 hasPublicationYear "1997" @default.
- W2079236410 type Work @default.
- W2079236410 sameAs 2079236410 @default.
- W2079236410 citedByCount "80" @default.
- W2079236410 countsByYear W20792364102014 @default.
- W2079236410 countsByYear W20792364102016 @default.
- W2079236410 countsByYear W20792364102018 @default.
- W2079236410 countsByYear W20792364102019 @default.
- W2079236410 crossrefType "journal-article" @default.
- W2079236410 hasAuthorship W2079236410A5009368307 @default.
- W2079236410 hasAuthorship W2079236410A5037190018 @default.
- W2079236410 hasAuthorship W2079236410A5047231135 @default.
- W2079236410 hasAuthorship W2079236410A5088941725 @default.
- W2079236410 hasConcept C112592302 @default.
- W2079236410 hasConcept C125439840 @default.
- W2079236410 hasConcept C15490471 @default.
- W2079236410 hasConcept C169760540 @default.
- W2079236410 hasConcept C170493617 @default.
- W2079236410 hasConcept C17077164 @default.
- W2079236410 hasConcept C185592680 @default.
- W2079236410 hasConcept C2780775167 @default.
- W2079236410 hasConcept C2781063702 @default.
- W2079236410 hasConcept C55493867 @default.
- W2079236410 hasConcept C86803240 @default.
- W2079236410 hasConcept C88016717 @default.
- W2079236410 hasConceptScore W2079236410C112592302 @default.
- W2079236410 hasConceptScore W2079236410C125439840 @default.
- W2079236410 hasConceptScore W2079236410C15490471 @default.
- W2079236410 hasConceptScore W2079236410C169760540 @default.
- W2079236410 hasConceptScore W2079236410C170493617 @default.
- W2079236410 hasConceptScore W2079236410C17077164 @default.
- W2079236410 hasConceptScore W2079236410C185592680 @default.
- W2079236410 hasConceptScore W2079236410C2780775167 @default.
- W2079236410 hasConceptScore W2079236410C2781063702 @default.
- W2079236410 hasConceptScore W2079236410C55493867 @default.
- W2079236410 hasConceptScore W2079236410C86803240 @default.
- W2079236410 hasConceptScore W2079236410C88016717 @default.
- W2079236410 hasIssue "4" @default.
- W2079236410 hasLocation W20792364101 @default.
- W2079236410 hasLocation W20792364102 @default.
- W2079236410 hasOpenAccess W2079236410 @default.
- W2079236410 hasPrimaryLocation W20792364101 @default.
- W2079236410 hasRelatedWork W115868519 @default.
- W2079236410 hasRelatedWork W1998768495 @default.
- W2079236410 hasRelatedWork W2032141855 @default.
- W2079236410 hasRelatedWork W2044962914 @default.
- W2079236410 hasRelatedWork W2066278525 @default.
- W2079236410 hasRelatedWork W2075385578 @default.
- W2079236410 hasRelatedWork W2751847892 @default.
- W2079236410 hasRelatedWork W3006582284 @default.
- W2079236410 hasRelatedWork W3148410686 @default.
- W2079236410 hasRelatedWork W4212915683 @default.
- W2079236410 hasVolume "81" @default.
- W2079236410 isParatext "false" @default.
- W2079236410 isRetracted "false" @default.
- W2079236410 magId "2079236410" @default.
- W2079236410 workType "article" @default.